Health Professions Review Board Suite 900, 747 Fort Street Victoria British Columbia Telephone: 250 953-4956 Toll Free: 1-888-953-4986 (within BC) Facsimile: 250 953-3195 Mailing Address: PO 9429 STN PROV GOVT Victoria BC V8W 9V1 Website: www.hprb.gov.bc.ca Email: hprbinfo@gov.bc.ca DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) (Grouped File: 2014-HPA-G22) In the matter of an application under section 50.6 of the Health Professions Act, R.S.B.C. 1996, c. 183, as amended, (the “Act”) for review of a complaint disposition made by an Inquiry Committee BETWEEN: The Complainant COMPLAINANT AND: The College of Pharmacists of BC AND: A Pharmacist REGISTRANT 1 AND: A Pharmacist REGISTRANT 2 AND: A Pharmacist REGISTRANT 3 COLLEGE Collectively “the Registrants” BEFORE: Marilyn Clark, Panel Chair DATE: Conducted by way of written submissions concluding on September 23, 2015 APPEARING: For the Complainant: I REVIEW BOARD self-represented For the College Esther Jeon, Complaints Resolution Office For Registrant 1: self-represented For Registrant 2: self-represented For Registrant 3: self-represented DECISION [1] Upon review of this file at the stage 1 hearing, I was unable to confirm under s. 50.6(8)(a) of the Act whether the investigation had been adequate and the disposition reasonable. I therefore requested submissions from the College and each of the Registrants at the stage 2 hearing of this matter. For the reasons that follow I have determined that the investigation was adequate and that the disposition falls within a range of rational outcomes. DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 2 II INTRODUCTION [2] The Complainant filed a complaint against three Pharmacists, the Registrants, following the death of his mother [the “Deceased”] after a fatal drug-drug interaction. [3] Following an investigation, the Inquiry Committee decided to take action under s. 36(1) of the Act, which allows the Inquiry Committee to request that a registrant consent to educational courses, a reprimand and/or any other action specified by the Inquiry Committee. This resulted in Registrants 2 and 3 each accepting a 30 day suspension of practice, a requirement for additional educational courses, preparation of papers relating to the impact of not being attentive to drug interactions, public announcement of their suspension on the College's website and subsequent audits of their practice. [4] Registrant 1, the pharmacy manager, was required to ensure a Pharmacy Policy was implemented at his pharmacy and that staff received training on assessing drugrelated problems. He also agreed to a practice audit at the pharmacy. [5] It is the Complainant's submission that Registrant 2 was negligent in not noting and following-up on the Level 2 warning that appeared on the pharmacy software identifying the danger of a drug-drug interaction when he filled a prescription for Allopurinol on June 29, 2012. This caused an interaction with an existing drug, Mercaptopurine. [6] Further, it is the Complainant's submission that Registrant 3 was negligent when he processed a renewal for Mercaptopurine on July 9, 2012, without following-up on the Level 2 warning that once again indicated the possible interaction with Allopurinal. [7] The Complainant is seeking more serious consequences for Registrants 2 and 3 who in his words "contributed to the premature, tortuous death of my mother". III HISTORY [8] The Deceased was an active, independent 76 year old. She suffered from a number of conditions including ulcerative colitis for which she was prescribed Mercaptopurine, chronic kidney disease, chronic obstructive lung disease, congestive heart failure and hypertension. She had been prescribed 12 medications in total. [9] On June 29, 2012, she visited her family doctor as a result of pain in her feet. She was diagnosed with gout and prescribed Allopurinal. [10] She joined her family on a camping trip for the last week of July and first week of August and began to experience unusual symptoms. When she returned from the vacation, she developed a blister on her foot and visited a locum physician who was concerned she had developed a bacterial infection. Blood tests were performed, the results of which were troubling, and she was transported to hospital. DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 3 [11] In the Emergency Department at the regional hospital, a physician reviewed her list of medications and quickly identified the Allopurinal and Mercaptopurine combination as the culprits advising the family "this should never have occurred, it was 100% preventable". A diagnosis of pancytopenia was quickly arrived at. [12] The Deceased was treated with multiple blood transfusions but developed sepsis and respiratory failure, deteriorating quickly until her death on September 3, 2012. The coroner declared the death accidental. IV DISCUSSION AND BACKGROUND A. Registrant 1 [13] Registrant 1, the Pharmacy Manager, was asked to explain the processes in place in his pharmacy with respect to the dispensing of medications and the documentation of interactions between drugs. [14] Registrant 1 explained "that it is standard practice for the pharmacist on duty to review the local and PharmaNet profiles for all new and refill prescriptions, as required by law, in order to identify and resolve any potential drug-related problems". He further explained the Level 1, 2 and 3 warnings that appear as a result of the PharmaNet software and how frequently such warnings appear. According to Registrant 1, "these interactions sometimes warrant discussions with the prescriber and the patient, which may result in monitoring of some sort, or a change to the prescribed treatment". Sometimes, level 2 warnings may be minor. He described that the practice at his pharmacy was for the pharmacist to write details of any communication on the prescription hard copy and to enter a note on the patient's screen. [15] In the case of the Deceased, Registrants 2 and 3 did not write any details of any communication on the hard copies and there were no entries on the patient’s screen. Registrant 1 suggested that during busy times the pharmacists might overlook a warning and he concludes that is what happened in this case. [16] In its review, the Inquiry Committee noted Registrant 1's comment, "being human in a busy retail setting, there are times when an interaction warning could get overlooked, and this appears to be what happened in this case. . ." [17] In her report to the Inquiry Committee, the Complaints Resolution Officer stated: [Registrant 1's] comment that "being human in a busy retail setting, there are times when an interaction warning could get overlooked, and this appears to be what happened in this case" . . . is an unacceptable excuse for "overlooking" a potential drug interaction. In fact, there is no good excuse for overlooking such an important aspect of pharmacy practice, busy or not. DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 4 B. Registrant 2 [18] Registrant 2 originally filled the prescription for Allopurinal on June 29, 2012. In response to the Inquiry Committee's request for a statement describing his recollection of filling the prescription and any discussions that occurred with the Deceased, Registrant 2 did not recall that fill but confirmed that he had indeed filled the Allopurinal prescription and described his customary practice as follows: To discuss why each medication was prescribed, how to take it, how long it will take to become effective and the commonly expected adverse effects a patient is likely to experience. Therefore I can say I believe that I would have followed this standard of care. In addition, as a matter of standard practice, I would counsel patients regarding any other concerns such as drug-drug interactions if I was aware that circumstances warranted such a discussion. [19] Registrant 2 went on to say that he would have likely noted the low dose of Allopurinol and the short duration of therapy and therefore it was unlikely he would have counselled the Deceased about its use. [20] The response of the Inquiry Committee is clear that the appropriate action for Registrant 2, after noting the drug-drug interaction, would have been to have a discussion with the prescribing physician about modifying the therapy by reducing the Mercaptopurine to 25% of the normal dose and then monitoring for toxic effects. The combination is not necessarily contraindicated but "modification to the therapy is recommended for managing the drug-drug interaction". [21] It is not possible to know whether a modification to the drug therapy would have been successful for the Deceased. It would not have been comforting to the Complainant to learn that a different approach might mean his mother would have survived. [22] Registrant 2 went on in his response to describe the measures implemented at the pharmacy to ensure there was no recurrence, including advising the prescribing physician of level 2 interactions. He also indicated they had marked Allopurinol in the pharmacy as being contraindicated for a patient prescribed Mercaptopurine. As stated in paragraph [20] above, as therapy modification is the recommended approach, the advice posted in the pharmacy ought to be altered. C. Registrant 3 [23] Registrant 3 dispensed the refill of Mercaptopurine to the Deceased on July 9, 2012. In response to the College's request for information, Registrant 3 wrote: On Monday, July 9/12 I, [Registrant 3], refilled a prescription for purinethol for [the Deceased]. As per professional standards her pharmacare profile was reviewed. A level 2 interaction, would have been noted but nothing on the hard copy would indicate we asked how the patient was feeling. [The Deceased] usually got her prescriptions herself and I DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 5 believe she was in the store that day. [Registrant 2] checked the physical prescription preparation and it was given to [the Deceased]. [24] This is the extent of the response from Registrant 3. [25] In fact, the renewal of the prescription for Mercaptopurine (purinethol) provided the pharmacy with a second opportunity to have a discussion with the dispensing physician about the drug-drug interaction. This opportunity was not taken. [26] Registrant 2 and 3 each neglected to take action when a drug-drug interaction was noted on the PharmaNet screen leading to the death of the Deceased. V ANALYSIS [27] The Review Board is limited by the Act to reviewing the disposition and determining whether the investigation was adequate and the disposition reasonable. Upon reviewing the disposition, I may confirm the disposition, direct the Inquiry Committee to make a disposition that was within their mandate or return it for reconsideration. I cannot change the disposition to one that I or the Complainant might have preferred. To be clear, if I find the investigation was adequate given the circumstances and the disposition falls within a range of reasonable outcomes, then I must confirm the decision of the Inquiry Committee. A. ADEQUACY OF THE INVESTIGATION [28] The College, upon receipt of the complaint on May 22, 2013, contacted Registrant 1, the Pharmacy Manager, requesting the names of the pharmacists who were involved in the dispensing of the drugs to the Deceased. Each of the Registrants, including the Pharmacy Manager, was asked to provide written statements. All of the communication appears to have been by letter and by email. There were no individual interviews. [29] In that regard, the Complaints Resolution Officer has stated that Registrants 2 and 3 admitted in their statements they had dispensed the drugs and had missed the drug interactions, so there was no issue of credibility. [30] The investigator engaged by the College provided a report based on the statements provided by the Registrants. In addition, the Inquiry Committee had for review: (a) the complaint filed by the Complainant which provided a thorough overview of the events leading up to his mother's death; (b) the Coroner's report; (c) the report from the College investigator; (d) the Deceased's PharmaNet records; (e) the Pharmacy's prescription records for the Deceased; DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 6 (f) the Professional Practice Policy; and (g) on-line documentation on Mercaptopurine's interaction monograph. [31] Although the Complainant was not interviewed during the course of the investigation, he had provided the thorough history in his complaint and responded in detail to the Inquiry Committee decision dated December 11, 2013. That response prompted another review by the Inquiry Committee in which they responded to the points made by the Complainant in their second disposition dated March 20, 2014. [32] The Review Board articulated in Review Board Decision No. 2009-HPA-0001(a) to 0004(a) at paragraph [97] the extent to which a College must investigate a complaint: A complainant is not entitled to a perfect investigation, but he or she is entitled to adequate investigation. Whether an investigation is adequate will depend on the facts. An investigation does not need to have been exhaustive in order to be adequate, provided that reasonable steps were taken to obtain the key information that would have affected the inquiry committee’s assessment of the complaint. [33] The Complainant argues that the investigation was based on email interactions and at no time were the Registrants interviewed in person. He believes that had the investigation begun as soon as it was apparent that the drug-drug interaction was the cause of the Deceased's condition and been conducted in person, there might have been an opportunity to interview the Deceased prior to her death. The Registrants were unaware of any reporting requirement; apparently neither was the family physician who prescribed the drugs nor the emergency room physician who identified the cause of the Deceased's illness. [34] The investigation which did not begin until the complaint was filed was surely not perfect. In-person interviews with the Registrants in their work location may have given a perspective that is not available through email communication. However, given the facts of the case, it is my view that the investigation can be considered adequate. B. REASONABLENESS OF THE DISPOSITION [35] The Panel Chair in Review Board Decision No. 2014-HPA-071(a) to 073(a), at paragraphs [12] and [13], described the task of the Review Board, when considering whether a disposition was reasonable and the test for determining reasonableness, as follows: [12] The legislature’s reference to the “reasonableness of the disposition” makes clear that the Review Board is not to ignore what the Inquiry Committee has done or to step into its shoes. On the other hand, by conferring the review mandate on a specialized Review Board rather than a generalist court as it could have done, the legislature must equally have recognized first that it is for the Review Board to determine the degree of deference that is appropriate in particular circumstances, and second that reasonableness is not self-applying; the Review Board is not a court and the application of the reasonableness test will necessarily reflect the Review Board’s specialized role and expertise. The DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 7 legislature has made clear that it falls within the Review Board’s exclusive jurisdiction to define and apply “reasonableness” within the context of reforms whose purpose is to ensure an appropriate degree of college accountability, section 50.63(1). [13] The test the Review Board has traditionally applied to determine reasonableness is whether the Inquiry Committee’s disposition “falls within the range of acceptable and rational solutions, and is, viewed in the context of the whole record, sufficiently justified, transparent and intelligible to be sustained.” I see no basis to depart from this view. I only note that the “range of acceptable and rational solutions” and what is “sufficient” justification, transparency and intelligibility in a particular case is a question to be determined by the Review Board on a case by case basis, applying its expertise and specialized role in good faith, and not simply by comparison to how a generalist court might apply the test on judicial review. [36] The Inquiry Committee pursued the course of action outlined in s. 33(6)(c), which allows the Inquiry Committee to “act under section 36”. Section 36(1), in turn, states as follows: (1) In relation to a matter investigated under section 33, the inquiry committee may request in writing that the registrant do one or more of the following: (a) undertake not to repeat the conduct to which the matter relates; (b) undertake to take educational courses specified by the inquiry committee; (c) consent to a reprimand; (d) undertake or consent to any other action specified by the inquiry committee. [37] The Inquiry Committee found that this case cast light on a number of practice deficiencies and was critical of all three Registrants. Neither Registrant 2 or Registrant 3 acted on the drug-related problem even after the level 2 interaction was highlighted on the PharmaNet screen upon originally filling the Allopurinal prescription and then when refilling the Mercaptopurine a few days later. Accordingly, the Inquiry Committee determined that both Registrants had breached the appropriate regulatory standard of care. [38] This particular drug-drug interaction is well documented. This information was available to the Registrants as every pharmacy is required to have at least one authorized library reference in the Drug Interactions category, in addition to the PharmaNet alert. [39] The three Registrants were each asked and agreed to consent to a number of undertakings with a goal of preventing such errors in the future, including in the case of Registrants 2 and 3: DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 8 (a) requiring them to follow identified steps for all prescription dispenses, including refills; (b) consent to a temporary suspension from practice for a period of thirty days; (c) complete specified courses available through the Faculty of Pharmaceutical Sciences at UBC with reinstatement to practice being conditional on the courses being completed; (d) provide a written summary to the Complaints Resolution Officer of what they learned in those UBC courses, such summary to be not less than two pages and include how they would alter their practice as a result of this incident and their recent course work; (e) provide a case summary of a journal article on managing drug-drug interactions for immunosuppressants; and (f) upon reinstatement, they would be subject to a practice audit. [40] The Inquiry Committee reminded Registrant 1, the Pharmacy Manager, of his duty to ensure a quality management program, as required in section 10 of the Pharmacy Operations and Drug Scheduling Act (PODSA): (a) maintains and enforces policies and procedures to comply with all legislation applicable to the operation of a community pharmacy, (b) monitors staff performance, equipment, facilities and adherence to the Community Pharmacy Standards of Practice, and (c) includes a process for reporting, documenting and following up on known, alleged and suspected errors, incidents and discrepancies. [41] Accordingly, Registrant 1 was required to "implement a pharmacy policy relating to the practice issues and deficiencies raised in this complaint, conduct an educational training [sic] for his staff and to comply with a practice audit at his pharmacy". [42] Further, the Inquiry Committee noted: There is no excuse for overlooking any DRP (Drug Related Problem) as managing drug interactions is an important aspect of pharmacy practice. Regardless of staffing levels, the pharmacy manager is vested with the responsibility of ensuring that registrant and pharmacy assistant staff levels are commensurate with the workload volume and patient care requirements at all times. [43] The Inquiry Committee did not treat this lightly. While it did not issue a formal citation, it requested, and Registrant 2 and Registrant 3 accepted, serious consequences, including suspension for 30 days and further education specific to the issue of drug therapies for each of them. It is evident that, had these consequences not been accepted, a citation and formal discipline proceedings would have followed. DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 9 [44] The Complainant is critical of the disposition in the following areas: 1. Allowing the Registrants to consent to their punishment in a consent agreement: this in the eyes of the Complainant allows them to consent or not. In fact, without consent, they would not have been able to continue to practice. 2. He suggests that drug-drug interactions always be reported and investigated. [45] The Coroner's Report identified the death as accidental and noted the deceased died "of sepsis and respiratory failure due to pancytopenia as a result of drug interaction between Mercaptopurine and Allopurinal. Congestive heart failure, chronic renal failure, chronic obstructive lung disease and hypertension were contributory factors". TUNING DOWN THE SYSTEM [46] One of the issues the Complainant brought forward was the statement the prescribing physician wrote in a letter to his College, the College of Physicians and Surgeons of BC, that "The community pharmacist informed me that because there are so many potential interactions between medications, they have to tune down their system not to flag less common or less troublesome interactions." [47] Registrant 1, in responding to this allegation, wrote: The software system we use (Kroll Windows) has never been altered or manipulated in any way with regards to the displaying of drug interaction warnings. In fact, until I read [the family physician's] comments, I had never even heard of such a practice. Since we rely on these drug interaction software programs every day, I cannot imagine a pharmacist intentionally altering them, or "tuning them down" in order to reduce warning messages. [48] The College contacted Kroll directly to determine if manipulation of the software alert system is possible. Kroll confirmed that their program does not allow manipulation of alerts at the store level. [49] Registrants 2 and 3 vehemently denied advising the family physician that they "tuned the system down" but Registrant 3 did recall having a conversation with the family physician who called him from the hospital on a weekend enquiring about his understanding that some alerts had been turned off. Registrant 3 advised the physician that some background programs, like on-hand quantity and a list of all generics for a drug, had been turned off as they slowed down the computer and were unnecessary in their pharmacy. The family physician was satisfied with the explanation, especially when he learned that the drug-drug interaction warning was on the Deceased's computer printouts for her prescriptions. EFFECT OF EVENTS ON REGISTRANTS [50] The Registrants have indicated their sorrow and regret over the outcome of this DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 10 event, the death of the Complainant's mother. The life paths of both Registrants 2 and 3 have been altered. [51] Registrant 2, in his June 29th response to the Complainant's April 21, 2015, Statement of Points, writes: The fallout from this matter has been very damaging personally. I have been under the care of a psychologist and on antidepressants since I was made aware of it. Furthermore in October, of 2014, I reached a suicidal state due to ongoing depression brought about by this incident, and was hospitalized in [nearby City] for several days on suicide watch. . . Furthermore, as of September 25, 2014, I voluntarily left practice and have remained inactive as I attempt to overcome my depression. [52] Registrant 3 has moved to another jurisdiction and has applied for licensing there. [53] Clearly, Registrants 2 and 3 have not only been disciplined by the College but continue to live with their own demons resulting from this event. CONTINUING EDUCATION REQUIREMENTS [54] I noted Registrant 2's summary of learnings from the courses he was required to attend as a result of the undertakings he and Registrant 3 had to fulfill as a part of their discipline. In that summary he frequently commented on how the world of research had changed since his graduation some 25 years previously. In particular, he commented on the value of internet search techniques he had newly learned. [55] The College requires registrants to complete a minimum of 15 hours of professional development on a minimum of "6 learning records" every year. This is mandatory and must be submitted annually upon a registrant's registration renewal. [56] The College Member profiles included in the Record do not disclose the fulfilment of the Registrants' annual continuing education. This is a concern for a number of reasons: ensuring that registrants fulfil the continuing education requirement; ensuring that the College's registration renewal process is thorough; and a concern throughout this review about the oversight and management provided the Registrants by the Pharmacy Manager, including guiding the continuing education needs of the individuals. VI CONCLUSION [57] The Complainant has suffered a loss in the death of his mother and has doggedly sought justice, whatever that looks like. It appears to me that for the Complainant, justice means severe discipline be assigned Registrant 2 and Registrant 3 and a formal process of reporting be established for all missed drug-drug interactions. I cannot disagree with this latter tenet. He is likely correct when he states that nothing would have happened had he not filed a complaint with the College. As he sought advice as to whom this tragedy should be reported, he was advised there is no reporting requirement. The extent DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 11 of the recommendations in the Coroner's Report to this College and to the College of Physicians and Surgeons was simply: "The circumstances of this death be reviewed for information and appropriate follow-up." [58] The investigation was adequate in that there was little else to discover. Two pharmacists ignored drug-drug interaction warnings leading to death and admitted they had done so. [59] The reasonableness of the disposition is a more difficult question. The disposition, which was agreed to, resulted in the remedial consequence the College Inquiry Committee thought appropriate, including in the case of Registrants 2 and 3, suspension of their licences for 30 days, public notification of their suspension, a requirement to take specified additional training and to submit to a practice audit. [60] One of the questions the Review Board must always consider in a case where a “request” under s. 36(1) was “accepted”, especially in a serious case, is whether the agreed outcome reasonably serves the public interest. That is always a risk in any process that might involve negotiation and ends in an agreement and does not proceed to formal discipline. In this case, however, I am satisfied that the process was legitimate and that the outcome was within the range of reasonable outcomes, and that the Inquiry Committee did not sacrifice the public interest with these consequences, which could just as easily have been the result of a formal discipline hearing. In my view, the disposition was reasonable. [61] Separate from the particular consequence to the Registrants, the Complainant would have been satisfied to some extent had the College taken steps to establish, on a more systemic level, necessary reporting requirements when drug-drug interactions occur and especially when serious injury or death occurs so that others do not suffer as has this family. To that I say: do not despair. That could still be an outcome of this complaint as the College considers the "appropriate follow-up" suggested by the Coroner. [62] The Institute for Safe Medication Practices Canada (ISMP) encourages healthcare workers to report deaths to the coroner if a medication error is suspected to have caused or contributed to a death, enhancing patient safety by sharing learning. The Canadian Medication Incident Reporting and Prevention System (CMIRPS) is a collaborative program of Health Canada, the Canadian Institute for Health Information (CIHI), the Institute for Safe Medication Practices Canada (ISMP Canada) and the Canadian Patient Safety Institute (CPSI). Its goal is to reduce and prevent harmful medication incidents in Canada. [63] There are at least three organizations that accept reports of incidents that lead to severe outcomes, including death, as a result of medication errors. While I have no authority to require it, I find the unique circumstances of this case warrant my respectfully offering some observations arising from the tragic circumstances of this case. One is that all health practitioners in British Columbia be required, as they are in the case of gunshot wounds, to report medication incidents with adverse outcomes in order to reduce the DECISION NO. 2014-HPA-106(a); 2014-HPA-107(a); 2014-HPA-108(a) Page 12 number of occurrences in future care. It should not be left to grieving families to report these incidents. [64] To bring a legislated requirement of this type into being, encompassing all health colleges operating under the Act, would likely be an optimal solution. Even where some errors might fall “between the cracks” in the functional gap between professions (as in this case, between medicine and pharmacy), a sector-wide reporting requirement would go a long distance toward ensuring that the maximum future learning and prevention benefits - perhaps including the updating of drug interaction databases - are extracted from unfortunate incidents. [65] Closer to home, I respectfully offer the same reporting suggestion to the College in this case, given the wide range of powers it possesses to regulate its registrants under its bylaw-making authority (e.g., ss. 19(1)(k), (k.1) and (x) of the Act). [66] I also encourage the College to review its continuing education requirements for College registrants, including the reporting, recording and monitoring of annual continuing education activities, and strengthen them if necessary. [67] I will reiterate that the Review Board has no formal authority to issue systemic directions in the course of a decision made in an application for review of an Inquiry Committee disposition. The suggestions set out in the above paragraphs are offered in the unusual circumstances of this case, and as a courtesy to the College and to the Province in the spirit of public protection that is the core duty of a College as set out in s. 16(1) of the Act. VII DECISION [68] I find the Inquiry Committee’s investigation adequate and the disposition reasonable as it falls within a range of acceptable and rational possibilities. Accordingly, the disposition is confirmed. [69] In making this decision, I have considered all of the information and submissions in the record whether or not specifically reiterated herein. “Marilyn Clark” Marilyn Clark, Panel Chair Health Professions Review Board November 26, 2015