Together, we can do this Strategies to Address British Columbia’s Prescription Opioid Crisis Recommendations from the British Columbia Node of the Canadian Research Initiative on Substance Misuse November 2015 1 Together, we can do this Strategies to Address British Columbia’s Prescription Opioid Crisis Recommendations from the British Columbia Node of the Canadian Research Initiative on Substance Misuse 30 Executive summary fig 1 Annual opioid dispensing (not including methadone) in BC, 2005–2013 25 20 15 10 Weak opioids 5 Strong opioids Fischer et al., 2014. * DDD = defined daily dose DDD/1000 population/day Recent events in British Columbia have highlighted the urgency with which policy makers, regulatory bodies and clinicians need to act together to address the public health harms related to pharmaceutical opioids and other addictive pharmaceutical drugs. This report briefly describes the provincial pharmaceutical opioid problem and provides several key recommendations for immediate steps to reduce fatal overdoses, misuse, addiction and other severe harms related to unsafe opioid prescribing in BC. 0 2005 2009 2013 1 The prescription opioid epidemic In addition to an increased rate of opioid prescribing, there is evidence of inappropriate and high-risk opioid prescribing practices in BC. For instance, while patients on methadone commonly have chronic pain, past research suggests that 35% of patients on methadone maintenance treatment in BC are co-prescribed opioids that are often not prescribed by the patient’s primary methadone provider.12 This is problematic since co-prescriptions with methadone have important safety considerations, as evidenced by a recent study of provincial mortality data found that methadone was involved in 25% of pharmaceutical opioid-related deaths in BC.13 Equally concerning are the persistently high rates of benzodiazepine prescribing in BC,14 given that co-prescription of benzodiazepines and opioids has long been known to be a major risk factor for fatal overdose.15-18 Coinciding with the dramatic increases in opioid prescribing in BC, there are high rates of opioid dependence, addiction and misuse that have contributed to significant health and social harms. In 2013, there were more than 330 deaths in BC related to illegal drug overdose including opioids. Of these deaths, 87% were accidental.19 Pharmaceutical opioids account for a large proportion of these deaths, to the extent that the number of pharmaceutical opioidfig 2 related deaths exceeds the number of deaths from motor 5 vehicle accidents involving Pharmaceuধcal opioids alcohol in BC (Figure 2).13,19–21 4 Furthermore, among the pharmaceutical opioidrelated deaths in BC, 93% 3 involved at least one other high-risk medication (e.g., benzodiazepines).21 Although 2 rates of prescription opioidrelated death in BC have 1 Alcohol/drug-related plateaued in recent years, the motor vehicle accidents province is still experiencing annual mortality rates of 0 close to 4 deaths per 100,000 2009 2010 2011 2012 2013 people.13 Year deaths per 100,000 people per year in BC Canada has the second highest opioid consumption rate among developed countries, with the rate of pharmaceutical opioid use tripling in Canada over the past decade.1-3 Despite similar rates of chronic pain across Canada, there is substantial variation in the rates and types of opioids prescribed across provinces.4-8 For example, British Columbia (BC) dispenses more than double the amount of opioids compared to Quebec, the lowest opioid dispensing province.6,8 Additionally, from 2005 to 2011, the rate of dispensing strong opioids in BC increased by almost 50% overall, including a 135% increase in oxycodone dispensation.6 Notably, these increases in opioid prescribing conflict with the increasing body of research suggesting that opioids may have limited long-term effectiveness for treating chronic non-cancer pain, and that the risk profile of opioids may outweigh their potential shortterm benefits in cases of mild to moderate acute pain.9-11 More people die in BC each year from Studies ha ve sug gested pharmaceutical opioids (including that approximately 40% of methadone) than from alcohol/drugprescribed pharmaceutical related motor vehicle accidents.13,19–21 opioid-related deaths occur among people who are prescribed opioids above recommended safe-dosing guidelines.22 Furthermore, deaths related to prescribed pharmaceutical opioids correlate strongly with rates of opioid dispensation in BC.23 In addition to opioid overdose and mortality,24 there are extensive health and social harms associated with pharmaceutical opioids, including injuries and trauma;25 increased risk of costly emergency department visits;26,27 diversion to street-based markets, drug dealing and other 2 addiction-associated petty crime.3,28 Additionally concerning is evidence highlighting the growing number of infants being born with opioid addiction in Canada.29 Finally, recent evidence has demonstrated that many individuals who initially used pharmaceutical opioids or benzodiazepines illicitly may eventually transition to heroin or intravenous drug use thus substantially increasing the risk for blood-borne infections and overdose.30-36 In the face of this evidence, change has been slow to come. This brief paper was prepared through the secretariat of the British Columbia node of the CIHR Canadian Research Initiative on Substance Misuse (CRISM). The development of this document included a range of expert stakeholders through the network’s membership and other experts (Appendix A). This urgent call to action outlines changes that can be immediately implemented in BC to substantially reduce the rates of overdose death, addiction and related harms that stem directly from the current system. Urgent need for action in British Columbia While the pharmaceutical opioid epidemic has emerged throughout North America, recent events in BC have highlighted the urgency with which BC policy makers must act to address the public health harms related to pharmaceutical opioids and other addictive pharmaceutical drugs. Despite the scale of the present public health problem, strategies to meaningfully address unsafe prescribing have not been implemented. This is despite the fact that, ultimately, prescribers are largely responsible for the burgeoning illicit market in pharmaceutical opioids that has developed on the streets of BC.37-40 In fact, the entry of organized crime groups into the manufacturing of counterfeit pharmaceutical opioids (which often contain fentanyl) to fuel the street market for illicit or diverted opioids is arguably a direct result of longstanding unsafe physician prescribing practices.41-43 Specifically, BC has witnessed a spike in fentanyl related overdoses and deaths. Within only two years, there has been a seven-fold increase in fentanyl detected deaths in BC (from 13 deaths in 2012 to 90 deaths in 2014), representing 25% of all illicit drug related deaths in the province in 2014.44,45 In 2015, there have been several high profile deaths from fentanyl in BC,46-48 as well as 16 cases of suspected fentanyl overdoses in a single day in Vancouver.49-51 This worsening of the situation has occurred despite focused drug-law enforcement on the illicit fentanyl trade that has included at least 11 search warrants, 8 charges and 500,000 pills seized in Metro Vancouver alone.41,52,53 Based on past evidence regarding the limited effectiveness of police seizures on controlling the availability of illicit drugs, it is unlikely that law enforcement efforts are a promising solution to this problem.54,55 In 2015, sixteen cases of suspected fentanyl overdoses were once reported in a single day in Vancouver. Equally concerning are the persistently high prescribing rates of benzodiazepines in BC. Benzodiazepines are sedating hypnotic medications that, despite limited evidence of effectiveness and clear evidence of harms (e.g., addiction, fatal overdose, etc.), continue to be regularly used to treat sleep disorders and other minor health conditions for which there are much safer alternatives. In fact, benzodiazepines remain among the most commonly prescribed and misused types of psychoactive drug in the world, despite their link to serious harms, including cognitive impairment and decline (i.e., dementia), accidents and injuries, dependence and addiction, and fatal overdose — especially when used in combination with opioids or alcohol.56-58 Locally, recent research has found that benzodiazepine use 3 was associated with elevated rates of HIV infection among a cohort of people who inject drugs, and addiction to benzodiazepines is known to be extremely difficult to treat.59 In light of these risks, many clinical guidelines now recommend against prescribing benzodiazepines, yet inappropriate prescribing has continued to persist in BC.14 As a result, the percentage of pharmaceutical opioid related overdose deaths involving benzodiazepines in BC increased 600% between 2004 and 2013.13 Areas for intervention In the wake of the crisis that exists in BC, there has yet to be sufficient action from various colleges (i.e., College of Physicians and Surgeons of BC, College of Pharmacists of BC, College of Registered Nurses of BC, College of Dental Surgeons of BC, College of Veterinarians of BC) or other regulatory bodies across the province. This situation is likely a result of these groups waiting on Health Canada for action, coupled with the fact that no single group (e.g., regulatory bodies, police, etc.) has a clear mandate to address the current epidemic. Fortunately, BC is uniquely positioned to rapidly implement several safeguards to reduce unsafe prescribing practices through the province’s PharmaNet system and other interventions. PharmaNet is an electronic information system that records data (e.g., drug name, dose, quantity, duration, prescribing practitioner, dispensing pharmacy) on all prescriptions dispensed at community pharmacies in BC.60 Previous research has suggested that the real-time, centralized nature of PharmaNet, which allows prescribers and pharmacists to access patients’ current prescription information, can be effective in reducing inappropriate prescriptions of opioids and benzodiazepines by approximately 30-50%.61 Notably, this study was performed at a time when only pharmacies had access to PharmaNet, suggesting that there is room for even greater reduction of inappropriate prescribing if PharmaNet is more widely utilized by prescribers and pharmacies. To this end, enabling physicians and nurse practitioners to access patients’ opioid prescription history promotes optimal opioid prescribing practices.62 However, presently, physicians and nurse practitioners in BC are able — but not required — to use PharmaNet when prescribing medications. Here, it is estimated that less than 30% of physicians in BC have enrolled for PharmaNet,62 which means that over 70% of BC physicians may be writing opioid prescriptions without knowing if the patient in front of them is already prescribed opioids from multiple other practitioners. This is a very real concern, as evidenced by the case of one BC resident who received more than 23,000 pills of oxycodone from more than 50 physicians and 100 pharmacies over five years.64 Over 70% of BC physicians may be writing opioid prescriptions without knowing if the patient in front of them is already prescribed opioids from multiple other practitioners. Additionally, practitioners who do not use PharmaNet may be unaware if a patient is receiving medications that pose high risk for overdose if coprescribed with opioids, such as benzodiazepines or methadone. Furthermore, it is not currently required that benzodiazepines are prescribed on a duplicate prescription pad, which is an additional safeguard that is in place for opioids and other medications that pose high risk for misuse, diversion or overdose.65 Prescription monitoring for benzodiazepines has already been enacted in other settings including Alberta and New York.66,67 A study of the New York triplicate prescription program found that benzodiazepine prescribing was reduced by nearly 50% after the program’s implementation. These reductions were sustained for at least seven years after the program’s implementation, and most 4 patients did not require supplemental medication once their benzodiazepine prescriptions were discontinued.67 In addition to clinic-level prescribing practices, due to common pain and injury presentations, emergency departments can be another source of opioids. One study conducted at Vancouver General Hospital found that patients who were prescribed opioids upon discharge from the emergency department had triple the odds of experiencing an adverse event within two weeks.68 Given the demands placed on emergency department staff for providing pain relief among injured and other patients who present to emergency rooms, research and educational interventions tailored to emergency department settings — such as clinical guidelines, electronic decision support tools, and clinician education — require resources to support opportunities for safer opioid prescribing in this environment. In the absence of the above safeguards, some limitations of Canadian prescribers should be noted. For instance, physicians in BC have traditionally received little training on how to safely prescribe opioids or how to identify and treat opioid addiction. In fact, only one third of Canadian universities provide mandatory instruction in pain management as part of undergraduate medical training. Not surprisingly, it has been estimated that only approximately 30% of Canadian family physicians feel strongly confident in their opioid prescribing skills.69,70 Furthermore, primary care physicians have demonstrated high rates of continuing ineffective opioid prescriptions, being unaware of opioid monitoring guidelines and demonstrating low levels of knowledge regarding safe opioid prescribing in the context of chronic pain treatment.62 Similarly, previous studies have found that up to 94% of primary care physicians may be unable to identify symptoms or methods of problematic substance use.71-73 Recommendations regarding the need for greater investment in prescriber education (including nurse practitioners and other prescribers) in addiction and pain management, including the role of non-opioid analgesics for pain management, are described on the next page. 5 Recommendations In light of the evidence and the unique characteristics of the system of care in BC, a number of steps should immediately be taken to reduce the harms of the pharmaceutical opioid epidemic in British Columbia. These steps include: STRATEGIES FOR IMPROVED PRESCRIBING PRACTICES 1. Make registration for PharmaNet free, and legally require all clinicians with prescribing authority to be registered for PharmaNet and routinely check patients’ PharmaNet profiles when writing prescriptions. Exemptions to this requirement could be provided for individuals who practice in areas without Internet access or with other barriers. 2. Revise duplicate prescription pads to include a checkbox indicating that the prescribing practitioner has fulfilled his or her legal responsibility to review a patient’s PharmaNet record, thereby ruling out duplicate or high-risk co-prescriptions. 3. Put in place enforcement measures to ensure that pharmacies are checking PharmaNet to confirm that duplicate prescriptions or other evidence of inappropriate medical care is further brought to the attention of prescribing practitioners and regulatory authorities. 4. Change requirements for benzodiazepine prescribing such that benzodiazepines require a prescription on a duplicate prescription pad, in the same way that opioid prescriptions must be written in BC.65,67 5. Implement a maximum upper dispense limit for the amount of opioids that a patient may be dispensed at any one time. STRATEGIES TO IMPROVE OPIOID ADDICTION CARE 6. Dedicate investments into addiction treatment. For instance, buprenorphine/naloxone—a proven treatment for opioid addiction—should be the first line pharmacotherapy option (along with methadone) for opioid addiction, given its superior safety profile with respect to overdose risk compared to methadone.74-77 7. Improve access to buprenorphine/naloxone by eliminating the requirement that prescribers must have methadone exemptions in order to prescribe buprenorphine/naloxone. This requirement is unnecessar y given the low misuse potential of buprenorphine/naloxone and the low number of buprenorphine/naloxone prescribers the exemption requirement creates.78 In lieu of the methadone exemption, prescribers would be required to complete an online training module on buprenorphine/naloxone prescribing. 8. Invest in recovery-oriented care for individuals with opioid addiction. 9. Consider comprehensive patient education with regards to risks of poly-substance use and overdose prevention, recognition and response including take home naloxone prescription.79,80 10. Increase prescribers’ capacity for opioid agonist treatments (e.g., methadone and buprenorphine/ naloxone) via novel collaborative strategies. LONG-TERM STRATEGIES TO IMPROVE PRESCRIBER KNOWLEDGE 11. Invest in BC’s medical curricula and continuing medical education for physicians, nurses and other clinicians in addiction diagnosis, treatment and recovery; pain management including the use of non-opioid analgesics; and safe opioid prescribing, including the potential for serious adverse effects when opioids are co-prescribed with benzodiazepines and other psychotropic medications.38,81 12. Coinciding with benzodiazepines transitioning to a duplicate prescription requirement, investment should be made in education for BC prescribers on the known serious harms and clinical limitations of benzodiazepines, as well as the availability of safer alternatives.82 13. Support research and educational interventions in emergency departments to enhance safer opioid prescribing practices in this setting.83-86 If these evidence-based recommendations are enacted quickly, BC has the potential to dramatically reduce fatal overdoses, abuse, addiction and other severe harms related to unsafe opioid prescribing. Together, we can do this. The time for action is now. 6 Appendix A: Contributors and endorsers 1. Keith Ahamad, MD, CCFP, Dip ABAM Family and Addiction Medicine Physician, Providence Health Care / Vancouver Coastal Health Research Scientist, B.C. Centre for Excellence in HIV/AIDS Clinical Assistant Professor, Faculty of Medicine, UBC 2. Sandra Allison, MPH, CCFP, FRCPC Chief Medical Health Officer, Northern Health Adjunct Professor, School of Health Sciences, UNBC Clinical Assistant Professor, School of Population and Public Health, UBC 3. 5. Bill Bullock, MD, CCFP Family and Addiction Medicine Physician, Victoria Community Detox 7. Susan Burgess, MD Family and Communty Medicine Physician, Providence Health Care / Vancouver Coastal Health Clinical Associate Professor, Faculty of Medicine, UBC 8. 13. 14. 10. 15. Executive Vice President, Clinical Integration and Renewal Providence Health Care Adjunct Professor, School of Nursing, UBC Richard Dubras, MSc, MEd Executive Director, Richmond Addiction Services Society British Columbia Association of Clinical Counsellors 16. Nadia Fairbairn, MD, FRCPC Fellow, St. Paul’s Hospital Goldcorp Addiction Medicine Fellowship 17. Caroline Ferris, MD, CCFP, FCFP Primary Care and Addiction Medicine Physician Clinical Assistant Professor, Faculty of Medicine, UBC 18. Michelle Fortin Co-Chair, B.C. Alliance for Mental Health/Illness and Problematic Substance Use Executive Director, Watari Counselling & Support Services Jane A. Buxton MOBS, MHSc, FRCPC David W. Byres, MSN, BA, RN, CHE Cassandra Djurfors, MD, CCFP Medical Coordinator, Raven Song Primary Care, Vancouver Coastal Health Mike Burns, MD, CCFP Professor and Director MPH Practicum, School of Population and Public Health, UBC Trevor A. Corneil, MHSc, MD, FCFP, FRCPC Chief Medical Health Officer, Interior Health Drug Overdose and Alert Partnership Committee Member Clinical Professor, School of Population and Public Health, UBC Family Physician, Providence Health Care 9. Veronic Clair, MD, MSc, CCFP, FRCPC, PhD Addiction Medicine Physician, Vancouver Coastal Health Adjunct Professor, Faculty of Health Sciences, SFU Clinical Faculty, Faculty of Medicine, UBC James I. Brooks, MD, FRCPC Medical Director, Communicable Disease Prevention and Control Service British Columbia Centre for Disease Control 6. 12. Neal Berger Executive Director, Cedars at Cobble Hill Addiction Treatment Centre Rashmi Chadha, MBChB, MScCH, CCFP, ABAM Addiction Medicine Physician, Vancouver Coastal Health Medical Consultant, College of Physicians and Surgeons of British Columbia Cecilia Benoit, PhD Fellow, Royal Society of Canada Fellow, Canadian Academy of Health Sciences Scientist, Centre for Addictions Research of B.C. Professor, Department of Sociology, University of Victoria 4. 11. 19. Emilie Gladstone, MPH Pharmaceutical Policy Researcher, Centre for Health Services and Policy Research, Faculty of Medicine, UBC 7 20. Silvia Guillemi, MD Assistant Director, J. Ruedy Immunodeficiency Clinic (IDC), St Paul’s Hospital Director of Clinical Education, B.C. Centre for Excellence in HIV/AIDS Clinical Associate Professor, Faculty of Medicine, UBC 21. David Hall, MD, CCFP Medical Director for Primary Care, Vancouver Coastal Health Medical Lead, Regional HIV Program, Vancouver Coastal Health 22. Scott Harrison, RN, BScN, MA, CCHNC Director Urban Health & HIV/AIDS, Providence Health Care Adjunct Professor, School of Nursing, UBC 23. Kanna Hayashi, PhD Research Scientist, Urban Health Research Initiative, B.C. Centre for Excellence in HIV/AIDS Assistant Professor, Faculty of Medicine, UBC 24. Lorne Hildebrand 33. Ronald Joe, MD Associate Medical Director, Addiction Services, Vancouver Coastal Health 27. 28. 29. 30. P.R.W. Kendall, B.C. Provincial Health Officer Thomas Kerr, PhD 34. 35. Brandon Marshall, PhD Assistant Professor, Department of Epidemiology, Brown University School of Public Health 36. Leslie McBain, Community Advocate Moms United and Mandated to Saving the lives of Drug Users (MumsDU) 37. Rita McCracken, MD, CCFP Associate Head, Providence Health Care Clinical Assistant Professor Faculty of Medicine, UBC 38. Garth McIver, MD Medical Consultant, B.C. Methadone Program (CPSBC) 39. Mark McLean, MD, FRCPC Addiction Medicine Physician, Providence Health Care / Vancouver Coastal Health 40. Ailve McNestry, MB, CCFP, CCBOM Deputy Registrar, Drug Programs College of Physicians & Surgeons of B.C. Director, Urban Health Research Initiative B.C. Centre for Excellence in HIV/AIDS Professor, Faculty of Medicine, UBC 41. Family and Addiction Medicine Physician, Providence Health Care Vancouver Native Health Society Medical Clinic 42. M-J Milloy, PhD Research Scientist, Urban Health Research Initiative, B.C. Centre for Excellence in HIV/AIDS Assistant Professor, Faculty of Medicine, UBC Piotr Klakowicz, MD, MPH, CCFP Erin Knight, MD, CFPC Julio S.G. Montaner, OC, OBC, MD, DSc (hon), FRCPC, FCCP, FACP, FRSC Professor and Head, UBC–Division of AIDS UBC and St. Paul’s Hospital Foundation Chair in AIDS Research Director, B.C. Centre for Excellence in HIV/AIDS, St. Paul’s Hospital, Providence Health Care Mel Krajden, MD, FRCPC Medical Head, Hepatitis, B.C. Centre for Disease Control Acting Medical Director, Public Health Laboratory, B.C. Centre for Disease Control Julia MacIsaac, MD, MPH, FRCPC Family and Addiction Medicine Physician, Providence Health Care Alliance Clinic, Surrey, B.C. LAIR Centre, Vancouver Fellow, St. Paul’s Hospital Goldcorp Addiction Medicine Fellowship 31. Leslie Lappalainen, MD, CCFP Family and Addiction Medicine Physician, Providence Health Care Clinical Instructor, Faculty of Medicine, UBC Executive Director, EDGEWOOD 26. Andrea Krüsi, PhD Research Scientist, Gender and Sexual Health Initiative, B.C. Centre for Excellence in HIV/AIDS Ramm Hering, MSc, MD, CCFP, Dip PH Family and Addiction Medicine Physician, Pandora Clinic 25. 32. 43. Steve Morgan, PhD Professor, School of Population and Public Health, UBC 8 44. Lisa Muhler, PhD in Addictions Counselling 54. Registered Psychologist Clinical Director, Top of the World Ranch Treatment Centre 45. Seonaid Nolan, MD, FRCPC, Dip ABAM Internal Medicine and Addiction Medicine Physician, Providence Health Care Research Scientist, Urban Health Research Initiative, B.C. Centre for Excellence in HIV/AIDS Clinical Assistant Professor, Faculty of Medicine, UBC 46. Family and Addiction Medicine Physician, Providence Health Care Vancouver Detox Physician, Vancouver Coastal Health 55. 56. Michael Norbury, MBChB, MSc, BSc (Hons), CCFP Daniel Paré, MD, CCFP 57. Gerrard Prigmore, MB, BCh, MRCGP, DFSRH, CCFP, Dip ABAM 58. Nitasha Puri, MD, CCFP, Dip ABAM 59. Family and Addiction Medicine Physician, Vancouver Coastal Health / Portland Hotel Medical Clinic / Fraser Health Authority Clinical Instructor, Faculty of Medicine, UBC 50. Dan Reist, MTh Knowledge Exchange Assistant Director Centre for Addictions Research of B.C., University of Victoria 51. Lindsey Richardson, DPhil Research Scientist, Urban Health Research Initiative, B.C. Centre for Excellence in HIV/AIDS Assistant Professor, Department of Sociology, UBC 52. Launette Rieb, MSc, MD Family and Addiction Medicine Physician Clinical Associate Professor, Faculty of Medicine, UBC 53. Kimberly Rutherford, MD, MSc, CCFP Medical Coordinator, Primary Outreach Services, Vancouver Coastal Health Medical Staff, St. Paul’s Hospital, Providence Health Care Clinical Instructor, Faculty of Medicine, UBC Kate Shannon, MPH, PhD Director, Gender and Sexual Health Initiative B.C. Centre for Excellence in HIV/AIDS Associate Professor of Medicine, Faculty of Medicine, UBC Associate Faculty, School of Population and Public Health, UBC David H. Smith, MD, Dip ABAM Okanagan Psychiatric Services, Interior Health Clinical Instructor, Faculty of Psychiatry, UBC Family and Addiction Medicine Physician, Prince George 49. Todd Sakakibara, MD, CCFP, FCFP, Dip ABAM Family and Addiction Medicine Physician, Vancouver Coastal Health Clinical Associate Professor, Faculty of Medicine, UBC Inner City Primary Care & Assertive Community Treatment Team, Vancouver Coastal Health Medical Coordinator, Downtown Community Health Centre Clinical Instructor, Faculty of Medicine, UBC 48. Mark Sadler, MC Addiction Counsellor Executive Director, Top of the World Ranch Treatment Centre Family and Addiction Medicine Physician, Vancouver Coastal Health 47. Andrea Ryan, BSc, MD, CCFP Marshall K. Smith Director of Corporate Development and Community Relations Cedars at Cobble Hill Addiction Treatment Centre 60. Kate Smolina, PhD Banting Postdoctoral Fellow. Centre for Health Services and Policy Research School of Population and Public Health, UBC 61. M. Eugenia Socías, MD Researcher, B.C. Centre for Excellence in HIV/ AIDS Postdoctoral Fellow, Department of Medicine, UBC 62. Tim Stockwell, PhD Director, Centre for Addictions Research of B.C. Professor, Department of Psychology, University of Victoria 63. Lorinda Strang Executive Director, Orchard Recovery Center 9 64. Christy Sutherland, MD, CCFP, Dip ABAM Medical Director, Portland Hotel Society Community Services Society Family and Addiction Medicine Physician, Providence Health Care Clinical Assistant Professor, Faculty of Medicine, UBC 65. David Tu, MD, CCFP Family and Addiction Medicine Physician, Vancouver Native Health Society Clinical Associate Professor, Faculty of Medicine, UBC 67. Devin Tucker, MD Addiction and Family Medicine Physician, Vancouver Coastal Health 68. Mark Tyndall, MD, ScD, FRCPC Executive Medical Director, B.C. Centre for Disease Control Deputy Provincial Health Officer, Province of British Columbia Director, UBC–BCCDC Research Institute Professor, School of Population and Public Health, UBC Karen Urbanoski, PhD Canada Research Chair in Substance Use, Addictions and Health Services Scientist, Centre for Addictions Research of B.C. Assistant Professor, University of Victoria 70. Sharon Vipler, MD Family and Addiction Medicine Physician, Providence Health Care Lianping Ti, PhD Researcher, B.C. Centre for Excellence in HIV/ AIDS Postdoctoral Fellow, Faculty of Medicine, UBC 66. 69. 71. Dan Werb, PhD Director, International Centre for Science in Drug Policy 72. Evan Wood, MD, PhD, ABIM, FRCPC Professor of Medicine, Canada Research Chair in Inner City Medicine, UBC Medical Director, Community Addiction Services, Vancouver Coastal Health / Providence Health Care 73. Steven Yau, MD, CCFP Primary Care Physician, Downtown Community Health Centre, Strathcona Mental Health Team and Assertive Community Treatment Team, Vancouver Coastal Health Clinical Assistant Professor, Faculty of Medicine, UBC Medical Director, IMG Programming, Division of Continuing Professional Development, Faculty of Medicine, UBC 10 Acknowledgments We wish to acknowledge Pauline Voon (PhD candidate) for research and writing assistance in preparing this document. We also wish to thank James Nakagawa, Cheyenne Johnson, Carmen Rock, Lianlian Ti, Elaine Fernandes, Diane Pépin, Jehnifer Benoit, and Deborah Graham for their editorial and administrative assistance. 11 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. References International Narcotics Control Board. Narcotic drugs: Estimated world requirements for 2012, statistics for 2010. Vienna, Austria: International Narcotics Control Board, 2011. Shield KD, Jones W, Rehm J, Fischer B. 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