Interoffice Cnt’responllence 3~ Subject: 19, 1977 ~.J. In o~der ~o he~p you with your preparations for N~r 7 to ~ ~rate ~s~nstb~ltty ~lCcee, cop~es of ~ tr~ar~ ~8 ~ ~ ~he last ~ttee ~ ~ 8, 1977, ~ in February. encl. 3MA10067215 Trial Exhibit 1202 3M_MN00000479 1145.0001 ORGANIC FLUORINE C~POUNI)S IN BLOOI) CHRONOLOGY AUGUST 22,, 1975 AUGUST 25, 1975 - DR. J. D. LA ZERTE RECEIVES CALL FROM W. S. GUY OF UNIVERSITY OF ROCHESTER. W, S, GUY, D. R. TAVES, AND W, S. BREY,JR. PRESENT A PAPER AT CHICA.r’.,-O ACS MEETING ENTITLED "CHARACTERISTICS AND CONCENTRATIONS OF ORGANIC FLUORO COMPOUNDS FOUND IN HUMAN TISSUES," SEPTEMBER 17-21, 1975 CENTRAL RESEARCH ANALYTICAL TO COMPAP,E C7FIsCOOH AND CBF17SO~H ~R SPECTRA WITH THAT REPORTED BY GUY ET AL. SEPT~ER 22, 1975 TAVES CALLS J. D. LA ZERTE TO DETE~INE IF 3M WILL FURTHER ANALYZE THEIR SAMPLE OF FLUOROCHEMiCAL. ALSO ASKS 3M TO OPEN CONTENTS OF FDA PETITION ON "SCOTCHBAN." OCTOBER, 1975 CENTRAL RESEARCH N~LYTICAL AGREES TO DETE~INE QUANTITY AND CHARACTER OF ORGANIC FLUORINE COMPOUNDS I~i HUMAN BLOOD. NOVEMBER 6, 1975 CENTRAL RESEARCH REPORTS THAT CBF17SO3H SPECTRA MATCHES THAT PRESE~T{D BY GUY, ET AL. DECEMBER 16, 1975 LA ZERTE, FREIER, AND LONG OF 3M VISIT GUY AND TAVES AT THE UNIVERSITY OF ROCHESTER. ~M PROPOSES, AND GUY AND TAVES AGREE THAT 3M WILL ATTEMPT TO ISOLATE AND IDENTIFY ORGANIC FLUORINE COMPOUNDS IN HUMAN BLOOD. 3MA 10067216 3M MNO0000480 1145.0002 CHRONOLOGY - PAGE 2 FEBRLIARY 17, 1976 CENTRAL RESEARCH ANALYTICAL DEVELOPS AN ACCURATE ANALYI’ICAL METHOD FOR DETERMINING PARTS PER BILLION QUANTITIES OF ORGANIC FLUORINE COMPOUNDS IN HUMAN BLOOD. METHOD TESTED ON BLOOD FROM AMERICAN RED CROSS AND VALUE AGREES WITH THOSE IN LITERATURE. APRIL 14, 1976 FOUR ~RATORY PEP,SONNEL HAVE BLOOD SAMPLES ANALYZED. CONCENT~TION OF ORGANIC FLUORINE COMPOO~S IN SOME PERSOIWNEL 100 TIMES NORMAL. JUNE 29, 1976 - SOME CH~LITE PERSONNEL SHOW ORGANIC FLUORINE COMPOUNDS AT 1,000 TIMES NORMAL. AUGUST 23,. 1976 - CORDOVA PERSONNEL E~POSED TO FLUOROCHEMICALS HAVE UP TO 50 TIMES NORMAL VALUES, AUGUST 26, 1976 CENTRAL RESEARCH ISOLATES AND IDENTIFIES ORGANIC FLUORINE COMPOUNDS FROM BLOOD OF CHEMOLITE PERSON AS CTF15COOH. SEPTEMBER 9, 1976 MICE FED "SCOTCHBAN." HAD q, o00 TIMES NORMAL ORGANIC FLUORINE COMPOUP~S. SEPTEMBER 17, 1976 - CFIF SO-," IDENTIFIED AS ORG~IO FLUORINE OCTOBER 8, 1976 - DECATUR PLANT PERSONNEL FOUND TO HAVE UP TO 300 TIMES NORMAL LEVELS. INDIVIDUALS EXPOSED TO FLUOROCHEMICALS OVER 20 YEARS AGO HAVE NORMAL ORGANIC FLUORINE COMPOUND LEVELS. 3MA10067217 3M MN00000481 1145.0003 CHRONOLOGY - PA6E 3 OCTOBER 28, 1976 - DR, LEON SINGER OF THE BIOCHEMISTRY DEPART~NT. UNIVERSITY OF MINNESOTA. CALLS TO OBTAIN SAMPLES OF CTFlsCOOH._ _ DR, SINGER REPORTS THAT HE HAS HAD CONVERSATIONS glTH TAVES. ALSO REPORTS THAT ANIP,ALS FED INORGANIC FLUORIDE SHOW INCREASES IN ORGANIC FLUORINE BLOOD ~WEL, 3 MA 10067218 3M MN00000482 1145.0004 OR6ANIC FLUOR]I~ COMPOUNDS IN BLOOD STATUS AT 94 NO EVIDENCE NOW OF RELATED HEALTH PROBLEMS, 3M ~ICAL DEPARTMENT INITIATING PR{)6~I TO STUDY BLOOD CHEMISTRY OF EXPOSED PERSONNEL, NO EVIDENCE THAT THE PROBLEM EXISTS WITH 3M’S CUSTOMERS. FUNDS ARE BUDGETED TO CONTINUE THE PROGRAM STUDY UNTIL WE ARE SATISFIED: (A,) THAT THERE IS NO HEALTH HAZARD INCURRED BY 3M EMPLOYEES; AND, (e.) THAT THE CONTINUED SALE OF OUR FLUOROCHE~IICALS FOR VARIOUS PURPOSES DOES NOT ENDANGER THE PUBLI C’S HEALTH. 3MA10067219 I II 3M MN00000483 1145.0005 FLUOR]NE C~ENT OF BLOOD SERI.I~ ORGANIC FLUORINE 1, LITERATURE VALUES 2, 3M CONTROLS 3. LABORATORY BUILDING 2~6 4. CORDOVA 5. CHEHOLITE 6, DECATUR P,P.B, 2 - 1~0 INORGANIC FLUORINE P.P,B, Ave. 30 ~ - 170 AvE. 20 10 - 80 qO - 60 q30 - 3,100 30 - 360 160 - 630 50 - 870 510 - 38,800 50 - gO 150 - %840 40 - 210 3MAt 0067220 3M MN00000484 1145.0006 SOURCES OF FLUORINE TOOTHPASTE, I)EIITAL CARE, FLUORIDIZED WATER ORGANIC 3M ~3 CF2 CF2 CF2 CF2 CF2 CF2COOfl CF3 CF2 CF2 CF2 CF2 CF2 CF2 CF2 S03H OTHERS STEROIDS TRANQUILIZERS ANESTHETICS HERBICIDES TEFLON AEROSOL PROPELLANTS REFRIGERANTS 3MA10067221 3M MN00000485 1145.0007