Dear Craig,

It is with regret that I offer my resignation. I have devoted my professional career to the
treatment of patients, the development of new therapies and advancing the state of knowledge
about cancer. Unfortunately, I fear my continued role leading clinical care and research will
become too much of a distraction to the hospital and its remarkable team of physicians,
researchers and staff. I have been extremely proud to work at MSK, where together we have
made enormous snides in our fight against cancer, and this effort must continue uninterrupted.

I take full responsibility for failing to make appropriate disclosures in scienti?c and medical
journals and at professional meetings. I have already updated disclosures in medical journals and
will continue to do so until the record is complete. My involvement in a number of
pharmaceutical and biotech companies, as well as consulting activities, were reported to and
reviewed by MSK That information was widely available to the public and members of the
academic research community through a variety of sources.

Beyond me, this is an important matter for the entire medical research ?eld. It is my hope that
this situation will inspire a doubling down on transparency in our ?eld and that MSK, other
research institutions, industry, publications, professional societies and other stakeholders
continue to work together to standardize the disclosure process.

I believe deeply in the importance of continued pioneering work. To ensure the that this
work continues smoothly I will, of course, remain available at your convenience to assist with
transition and related matters.

I look forward to continuing to be involved in the ?ght against cancer and I will follow all the
advances coming from MSK with great interest

With best re ds,



Jose

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