2.2 Investigator: Ho, Samuel
P?ject Title: Integrated Approaches for Identifying Molecular Targets in Alcoholic
Hepatitis
Meet ID: 1167598
Protocol#: H120108
Application Initial Protocol
Reviewer: Martina Buck
Reviewer Summary/Comments: The PI proposes taking transjugular liver pressures and
biopsies, blood, urine, and stool from Veteran patients with alcoholic hepatitis. Pregnant
women are included as are decompensated cirrhotic patients. This cohort has severe
medical risks for this procedure. The reviewer had a number of additional concerns
regarding subject safety and standard of care. These were communicated to the VADSHS
IRB for follow up. The staff list is incomplete. The description of the project is missing.
The hazards are incomplete. The proposal has major inaccuracies and missing
information that makes it impossible to evaluate.