From: Melo Craig

seat: --Aprillzola ll 03 AM

To: hejk
suhjoct: Re: Success!
near 1K,

liust want you to know how i feel about this use of mum in humans. I think you are taking a big risk and I on ma! want
anyone to think that applove of what you are doing, In any case the ecliteil I hope will not assume they are
resistant to hlv, although they may be, I'm not aware oi anything, but its possible the has some functions we
don't know of, so there is rhe risk that the patients will be deficient in some way. There is also a real chance for
chromosomal abnormalities and off target cumng.

I'm 507w I Cannot be move supportlve of effort, I know you mean well.

sincerely,
Craig

non: hEl'k --

Date _Aprill2018 a: 10:18 AM
Tn: Cr Mello 

Subjen: Re: Success!
Dear Craig.

I got your message, I thought you would be interested in iealmng more about me embryo genome editing, I will not
update the news to you in future.

The medical reason for performing the cats genome editing is acting like vaccine" for their babies, to proVide
life-long protection against HIV infection. lt is not urgent, but it is useful.

Regards,
JK

Jianku'i He
Associate Professor
Department of Biology, su5Tech

Original Message