From: Grennan, William [/O=BARDIOU=CRN AG/CN=RECIPIENTS/CN=WILLIA MG] Date: 3/31/2004 4:28:55 PM To: Blank, Thiemo [Thiechlank@crbardcom], Darcis, Roger [Roger.Darois@crbard.ccm] CC: Koppenberg, Chris [Chris.Koppenborg@crbard.ccm]‚ Dchrd, John [John.DeF ord@crb ard.ccm]‚ McDermott, Jack [Jack.McDermott@crbardcom] Subject: RE: need advice fcr Pclypropylen vendor Thiemo, I am sending out to your attention today 20 lbs ofthe Montell (Basell) PP-6523 resin. The Manufacturer's lot number is DA17BCCO3. The FedEx Tracking number is 6259 0385 8413. Good luck With your mclding trials. Bill ----- Original Message—…- Frcm: Blank, Thiemo Sent: Monday, March 29, 2004 2:30 AM To: Grennan, William; Darcis, Roger Cc: Koppenborg, Chris; DeFord, ] ohn; MeDerm0tt, Jack Subject: RE: need advice for Pclyprcpylen vendor Bill, Thanks a lot for immediate careing and the info below. I can assure you that I understand the sensitivity ofthe supplier issue and therefore won’t contact the supplier directly. My best regards Thiemo ————— Original Message—… From: Grennan, William Sent: Freitag, 26. März 2004 18:51 Tc: Blank, Thiemo; Darcis, Roger Cc: Koppenbcrg, Chris; Dchrd, John; McDermott, Jack Subject: RE: need advice fcr Pclyprcpylen vendor Thiemo, I have requested a 10 kg sample ofthe Mcntell resin PP—6523 from our extrusicn vendor. As soon as I receive it CONFIDENTIAL — PRODUCED PURSUANT TO PROTECTIVE ORDER AVA2E8262831 Iwill immediately FedEx the sample to your attention at Angiomed. This PP material is the only one that we have access to. However, I do know that Basel] Polyolefins Company bought out Monteii a few years ago and produces our Montell PP-6523 resin. The have a polypropylene manufacturing facility in Bayreuth, Germany that compounds a broad range of PP product. Below I have listed their product groups: Moplen,pro—fax Polypropylene homopolymer, random and impact copolymer products based on Ziegler—Natta catalysts Metocene Resin family based on single-site catalysts Adstif High crystallinity polyproylene with very high stiffness _ Clyrell í Polyolefinic resins with an outstanding combination of transparency and impact strength Pro-fax Ultra High performance polypropylene resins Once again we need to be certain that we don't contact the resin supplier directly due to the sensitivity of our implant application. Possibly you could ask your injection molding source to request other resin samples for you. Let me know if I can be of further help. Bill Bill Grennan Senior Advanced Manufacturing Engineer Davol Inc. 100 Sockanossett Crossroad Cranston, RI 02920 USA Tel: 1-40L463—7000 x2814 Fax: 1-401-946-7130 E—mail: william.grennan@crb ard.com ————— Original Message—…— Frorn: Blank, Thiemo Sent: Friday, March 26, 2004 8:05 AM To: Grennan, William; Darcis, Roger Cc: Koppenberg, Chris; DeFord, John; McDermott, Jack Subject: RE: need advice for Polypropyl en vendor Thanks Roger and Bill for your quick resp onse — CONFIDENTIAL — PRODUCED PURSUANT TO PROTECTIVE ORDER AVA2E8262832 I would very much like to make use of your offer to send us some samples for a trial. This way we avoid any potential confidentiality issues — since we do not need to contact the manufacturer or even disclose the material name and source to our microinjection partner. 5 —10 kg of the "Montell resin PP—6523" would be enough for us for a first shot. Ifyou have also access / er aan recommend a PP material with a higher melt mass flow rate (better suited for a micro injection melding process) I would be very interested too. Thanks again for your immediate help and best regards from Germany Thiemo ---—-Original Message ----- From: Grennan, William > Sent: Donnerstag, 25. März 2004 22:12 ‘_ To: Darcis, Roger; Blank, Thiemo Cc: Koppenborg, Chris; DeFord, John; McDermott, lack Subject: RE: need advice for Polypropylen vendor Dear Thiemo, We currently purchase (2) different 6.3 mil polypropylene monofilaments for our mesh products that are extruded from polypropylene resins. We supply the extrusion equipment and our vendor purchases the resins and extrudes the monofilament for us. The (2) different resins are as follows: —Phillips Marlex resin HGX-O3 0—01 —Montell resin PP-6523 Ï have procurement specifications for the monofilament materials only (attached). However, you can access the resin manufacturer’s web sites and print out copies of the actual resin specifications or I can request hard copies from our extrusion vendor and forward them to you. Let me know if you need additional information. Bill Bill Grennan Senior Advanced Manufacturing Engineer Davol Inc. 100 Sockanossett Crossroad Cranston, RI 02920 USA Tel: 1—401—463 —7000 X2814 Fax: 1—401—946—7130 CONFIDENTIAL — PRODUCED PURSUANT TO PROTECTIVE ORDER AVA2E8262833 ————— Original Message-…- From: Darcis, Roger Sent: Thursday, March 25, 2004 12:06 PM To: Blank, Thiemo Cc: Koppenberg, Chris; Grennan, William; DeFord, John Subject: RE: need advice for Polypropylen vendor Dear Thiemo, I am forwarding your Email to one of our engineers, Bill Grennan who you might have met in Miami. He will send you information on the polypropylene resins we get from 2 different suppliers. We have full bio testing on tile for a permanent implant we could share with you. ' IMPORTANT...the5e suppliers will likely not be interested in a medical application due to product liability concerns. We purchase our polypropylene monofilament from an extrusion supplier who purchases the resin directly from the resin manufacturers. Thus, it is likely that they do not know of our implant application. Please do NOT mention Davol's name in any discussions with these manufacturers. In fact, I would advise purchasing the resin through a 3rd party, not the resin supplier to avoid a supply issue once the medical application is discovered. Ifyou need the resin we use for samples or trials, we can get you any amount you need so you do not have to talk to the resin manufacturer. Let me know if we can help further. With warm regards, Roger Darcis ————— Original Message-…— From: Blank, Thiemo Sent: Thursday, March 25, 2004 11:16 AM To: Darois, Roger ; Subject: need advice for Polypropylen vendor Dear Roger, It was nice meeting you at Miami - hope you don't mind bothering you with the following request: We are looking in a research project for a polypropylen polymer that can be used in combination with & stent for implantation into peripheral vascular arteries. I know that you have alot of expertise with polypropylen. Therefore I thought you might be able to name a vendor and brand name to me that you would think provides the best raw material from the biocomp. point of view. Thanks a lot for yo'ur advice . ‘ Best regards Thiemo CONF1DENTIAL — PRODUCED PURSUANT TO PROTECTIVE ORDER AVA2E8262834 Thiemo Blank, PhD Senior Manager Research and New Technology Progr. Angìomed GmbH &Co Medizintechnik KG Wachhausstr. 6 76227 Karlsruhe Germany Phone: ++49 721 9445 332 Fax: ++49 721 9445 215 e_maìlí miemo.blank@crbard.com CONFIDENTIAL — PRODUCED PURSUANT TO PROTECTIVE ORDER AVA2E8262835