Denagard? Singling him out is never easy. ?amulm hydrogen fumarate Whole-herd health Study: Effects of Different Antibiotic Feeding Programs1 A commercial population ofapproximately 1,150 growing pigs averaging approximately 75 lb with a known history of swine pneumonia and bacterial enteritis was studied to understand the effects of different antibiotic programs. Con?rmation ofthe disease-causing bacterial agents (Pasteurello multocida, Escherichia coli and Salmonella Choleraesuis) was determined using laboratory diagnostics. STUDY DESIGN: - 9~week?old pigs averaging approximately 75 lb were placed and acclimated in the barn for 7 days - Total pigs: approximately 1,150 pigs (approx. 25 per pen) - Total pens: 5+6 single-gender pens of growing pigs were utilized in a randomized complete block design - Total replicates: 23 per treatment - Weights were recorded on days the time of marketing - Live weight, average daily gain (ADG), average daily feed intake (ADFI), feed to gain calculated), and gain to feed calculated) were collected and reported by pen - Live weight, hot carcass weight (HCW), and carcass yield were collected and reported by pen TREATMENT GROUPS: Treatment 1 Treatment 2 Negative control (no medication) Denagard 35 grams/ton 400 grams/ton CTC from day PERIOD 1 PERIODZ PERIOD3 STUDY DAY 21 STUDY DAY 61 STUDY DAY 117? DY DAY 0 SALULOTMENT BODY WEIGHT BODY WEIGHT BODY WEIGHT END OF 1st PULSE END OF 2nd PULSE END OF MARKETING STUDY DAY 7 STUDY DAY A9 STUDY DAY 39 BODY WEIGHT BODY WEIGHT BODY WEIGHT START OF 1st PULSE START OF 2nd PULSE START OF MARKETING Disease scores (coughing, diarrhea, lameness, antibiotic treatments) collected daily. MARKETING STRATEGY: . Each pen was marketed using the same schedule: Group 1 (Day 90): Heaviest 12% of pen 3 pigs) - Group 2 (Day 104): Next heaviest 24pigs) where hot carcass weight (HCW) was recorded. - Group 3 {Day 110 or 111): Next heaviest 48pigs) - Group 4 (Day 118): Final 12% of pen 3 pigs) . The pigs were weighed the day before shipment for slaughter and transported to a commercial slaughter facility . . Study Results TABLE 1. DISEASE INCIDENCE FROM DAY 0 TO STUDY END DIETARY TREATMENT CONTROL DENAGARD CTC -. NO. OF PENS 23 23 29261753 mo 0.5.9. (I. LAMENESSNOOBSIPEN . 6.3.qu .5..37.8. (.0be . RESPIRATORY0830650173050 1035,. 2244 (0001 different superscripts were statistically different (p 0.05). - *DBS=obser\red. TABLE 2. OVERALL RESULTS SUMMARY FROM DAY 0 TO STUDY END DIETARY TREATMENT CONTROL DENAGARD CTC S.E.M. P-VALUE NO. OF PENS 23 23 I 7.5.1 7.5.0 0.30. .0.I3..0 . 3 .I..0..8. 3-1-43; 2. Quay??I 6.0.1. .- ADFILBS 6..II.8.II 63.0; 6.0.9; 6.6.0.5 2..8..0 2%1- Eli-0'23? 051 n. GZF 0.358 0.357 0.0027 0.49 MORTALITYI .2.0.9. If); ?0.5.1 2.3937. 2.3.ng .I.9..6. .0..O.S CARCASSYIELDOA) 7.5.1.6; 7604 . 6.55 ?:M?eans with different superscripts were statistically different (P 0.05). "Includes morbidity and mortality. CHART 1. BODY WEIGHT ALL MARKETING GROUPS 325 320.6 318.1 320 315.9? - 315 314.3 312.5? 00 309.0 310-8" 310 307291.7 290 285 I 280 275? Group 1 Group 2 Group 3 Group 4 Overall wMeans with differentsuperscripls were statistically different(Ps 0.05}. I Den?agard CTC Key Findings Incidence of disease for pens treated with Denagard CTC was lower than in the control group. Additionally, there was a reduced need to treat respiratory disease, diarrhea and lameness with antibiotics for those in the Denagard CTC group. Pens treated with Denagard CTC performed better than the control grbup. By controlling on?label pathogens, this study resulted in: 3.5 lb heavier?nal weight - 1.4% better ADG - 1.9% improved ADFI 4. 2.3 lb heavier HCW - Don'twaltfor Pig Zero Whole-herd health When it comes to treating disease on your operation, isolating the source can be difficult. So, protect the population with the proactive choice that?s right for your herd and best for your business. Denagard and chlortetracycline (CTC) control swine dysentery associated with hyodysenteriae susceptible to tiamulin, and treats swine bacterial enteritis caused by Escherichia coli and Salmonella Choleraesuis sensitive to CTC, and bacterial pneumonia caused by Pasteurella multocida sensitive to CTC. Denagard and CTC both act at the ribOsomal level, inhibiting protein but their binding sites are different. Together, the two antibiotics increase the activity against labeled pathogens and enlarge the spectrum of control to certain gram- negative bacteria. While using Denagard alone does not require a Veterinary Feed Directive (VFD), using Denagard CTC does. Denagard? tiamuiin hydrogen fumarate Are you doing what?s right for your herd and best for your business? Talk to your local Elanco sales representative or technical consultant to learn more about protecting whole-herd health with Denagard. The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Denagard 10 Premix Denagard CTC Indications: Indications: For control of swine dysentery associated with hyodyseni?eriae For the control of swine dysentery associated with hyadysenteriae susceptible to tiamulin: susceptible to tiamulin and for treatment of swine bacterial enteritis caused by . Feed 35 gi?ton Escherichia call and Salmonella Choleraesuis sensitive to chlortetracycline and treatment of bacterial pneumonia caused by Pasteurella multacida sensitive to - Feed continuously as sole ration chlortetracycline: 2?day Withdrawal . 35 g/ton of Denagard 400 g/ton (10 mg/lb body weight For treatment of swine dysentery associated with hyaa?ysenreriae in daily divided doses) CTC susceptible to tiamulin: - Feed 200 gitan - Feed for 11+ days for treatment . Feed for 14 days . 2-day withdrawal Using Denagard alone does not require a Veterinary Feed Directive Using - 7?day Withdrawal Denagard CTC does require a VFD. For control of ileitis associated with tan/same intraceh?ulari's susceptible . to tiamulin: Caution: Federal law restricts medicated feed containing this veterinary feed . Feed 35 g/ton directive (VFD) drug to use by or on the order of a licensed veterinarian. - Feed for not less than 10 days - 2-day withdrawal Important Safety Information - Swine being treated with Denagard (tiamulin) should not have access to feeds containing polyether ionophares lasalocid, monensin, narasin, salinomycin and semduramicin) as adverse reactions may occur. - If signs of toxicity occur, discontinue use. - Withdraw days before slaughter at 200 giton and 2 days before slaughter at 35 giton. - Keep out of reach of children. Avoid contact with skin. . For use in swine only. - The effects of tiamulin on swine reproductive performance, pregnancy and?lactation have not been determined. Denagard LC Important Safety Information Indications: Swine being treated with Denagard (tiamulin) should not have For treatment of swine dysentery associated with hyadysenreriae access feeds containing polyether ionophore'slleg. lasalOCid. susceptible to tiamulin: monensm. narasm, salinomycm and semduramicm) as adverse .. . . . reactions ma occur. - Utilize Denagard LC in drinking water at 3.5 mg/lb (60 ppm} for ?ve days - Ifsigns of toxicity occur, discontinue use of medicated water and . . . . . . replace with clean, fresh water. For treatment of swme pneumonia assooated With Actrnabacri?ius plearopneumam?ae susceptible to tiamulin: - Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg/lb and 7 days before slaughter following treatment at 10.5 mgi?lb. - Keep out of reach of children. Avoid contact with skin. - Utilize Denagard LC in drinking water at 10.5 mg/lb (180 ppm) for ?ve consecutive days - For use in drinking water of swine only. Prepare fresh medicated water daily. The effects of tiamulin on swine reproductive ?Elanco Animal Health. Data on ?le. performance, pregnancy and lactation have not been determined. Denagard. Elanco and the diagonal bar logo are trademarks of Elanco or its af?liates. . If no response to treatment is obtained within 5 days re?establish 2018 Elanco or its af?liates. the diagnosis. Elanco supports the use of shared class antibiotics for therapeutic uses while under the oversight ofa veterinarian. More details on Elanco's Antibiotic, Welfare and Sustainability Policies can be found on USSBUDENODD26 I