OBJECTIVE

To investigate the association between prenatal
exposure to per?uoralkyl substances (PFASs) and
hospital admission due to infectious disease in
children up to 5 years of age.

METHODS

In the Odense Child Cohort, serum concentrations of ?ve
PFASs i.e. PFOS, PFOA, PFDA and PFNA were
measured in 1699 pregnant women before gestational
week 16 in the period 2010?2012. Data on hospital
admissions of their children due to infectious disease were
collected from the Regional Health Authorities from birth
until 2015. Twins and children born preterm (<32 weeks)

were excluded.

Statistics: Diagnoses were grouped into three categories:
upper respiratory tract infections, lower respiratory tract
infections and other infections. Associations were
investigated using logistic and negative binomial
regression models adjusted for maternal educational level

and parity.

RESULTS

A doubling in maternel serum
concentration of PFOS and PFOA was

CONCLUSION

Prenatal exposure to PFOS and PFOA was associated
with hospitalization due to infectious disease. A higher
rate of hospitalization was seen for lower respiratory
tract infections.

DESCRIPTIVE STATISTICS

Admission to hospital
At least once: 561 (24.5 
Respiratory tract infection: 56.5 of admissions

390 children had 1 admission
106 children had 2 admissions
65 children had 3 or more

Maternal PFAS concentrations

Median (p25-p75)

PFOS: 7.51 (6.13-11.20) ng/mL
PFOA: 1.68 (1.15-2.33) ng/mL

0.32 (0.21-0.42) ng/mL

PFDA: 0.27 (0.21-0.35) ng/mL

PFNA: 0.70 (0.50?0.91) ng/mL

Measurable in 99% of samples

 



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