22 0 34 9 6' 5. PFOA Chronic Summary Male Liver Incidence Post Wean Exposure Sex Organ Lesion G/L 0 20 40 80 Male Liver Adenoma 0 0 0 7* 11* Male Liver Adenoma 300 0 1 5 10* Male Liver Carcinoma 0 0 0 0 0 Male Liver Carcinoma 300 0 0 0 4 Male Liver Adenoma and Carcinoma 0 0 0 7* 11* Male Liver Adenoma and Carcinoma 300 0 1 5 12* G/L = Gestation/Lactation Exposure 50 animals evaluated per group Male Pancreas Incidence Pancreas Post Wean Exposure Sex Organ Lesion G/L 0 20 40 80 Male Pancreas Acinus Hyperplasia 0 18 [2.7] 32 [3.7]* 37 [3.2]* 31 [3.2]* Male Pancreas Acinus Hyperplasia 300 23 [2.7] 27 [3.2] 38 [3.3]* 33 [3.4]* Male Pancreas Adenoma 0 3 28* 26* 32* Male Pancreas Adenoma 300 7 18* 30* 30* Male Pancreas Carcinoma 0 0 3 1 3 Male Pancreas Carcinoma 300 0 2 1 3 Male Pancreas Adenoma or Carcinoma 0 3 29* 26* 32* Male Pancreas Adenoma or Carcinoma 300 7 20* 30* 30* G/L = Gestation/Lactation Exposure; 50 animals evaluated; [ ] denotes severity score of 1 to 5 Female Hepatocellular Incidence Post Wean Exposure Sex Site Neoplasm G/L 0 300 1000 Female Liver Adenoma 0 2 0 1 Female Liver Adenoma 150 Female Liver Adenoma 300 Female Liver Carcinoma 0 Female Liver Carcinoma 150 Female Liver Carcinoma 300 Female Liver Adenoma and Carcinoma 0 Female Liver Adenoma and Carcinoma 150 Female Liver Adenoma and Carcinoma 300 G/L = Gestation/Lactation Exposure 50 animals evaluated per group 0 3 1 1 3 0 4 3 1 4 0 6 Female Pancreas Incidence Acinar Cell Tumors (ACT) Sex Site Post Wean Exposure Neoplasm G/L 0 300 1000 Female Pancreas Adenoma 0 0 0 1 Female Pancreas Adenoma 150 Female Pancreas Adenoma 300 Female Pancreas Carcinoma 0 Female Pancreas Carcinoma 150 Female Pancreas Carcinoma 300 Female Pancreas Adenoma and Carcinoma 0 Female Pancreas Adenoma and Carcinoma 150 Female Pancreas Adenoma and Carcinoma 300 Female Pancreas Duct, Adenocarcinoma 0 Female Pancreas Duct, Adenocarcinoma 150 Female Pancreas Duct, Adenocarcinoma 300 G/L = Gestation/Lactation Exposure 50 animals evaluated per group 0 3 0 0 2 0 2 0 0 2 0 5 0 0 0 0 1