Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 First Dose M/F: 07/27/09 / NA Lab: BAT Custom Rpt (Litter-Based) -- 0-0, 0-20, 0-40, 0-80 NTP Study Number: C20614B Lock Date: 01/10/2012 Cage Range: ALL Date Range: ALL Reasons For Removal: 25021 TSAC Removal Date Range: ALL Treatment Groups: Include 001 0/0 ppm Include 007 0/80 ppm Study Gender: Male TDMSE Version: 2.5.0.0_sfh PWG Approval Date: NONE 25020 NATD 25019 MSAC Include 003 0/20 ppm Include 005 0/40 ppm Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 First Dose M/F: 07/27/09 / NA Lab: BAT FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED. Adrenal Cortex Adrenal Medulla Brain Islets, Pancreatic Liver Pancreas Pituitary Gland Prostate Testes Thyroid Gland Page 2 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 First Dose M/F: 07/27/09 / NA Lab: BAT SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF PERFLUOROOCTANOIC ACID MALE RATS Organ Morphology Adrenal Cortex Adrenal Medulla Adenoma Pheochromocytoma Benign Pheochromocytoma: Benign, Complex, Malignant, NOS Hepatocellular Adenoma Adenoma Carcinoma or Adenoma Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma Squamous Cell Papilloma, Papilloma, or Keratoacanthoma Adenoma Benign Tumors Malignant and Benign Tumors Liver Pancreas Skin Thyroid Gland: C-Cell All Organs Page 3 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 0/50 (0%) 0/50 (0%) 0/50 (0%) 3/50 (6%) LITTERS (b) 0/25 (0%) 0/25 (0%) 0/25 (0%) 3/25 (12%) POLY-3 RATE (c) 0/43.13 0/47.35 0/42.02 3/41.66 POLY-3 PERCENT (g) 0% 0% 0% 7.2% TERMINAL (d) 0/36 (0%) 0/42 (0%) 0/35 (0%) 3/37 (8%) FIRST INCIDENCE --- --- --- 743 (T) POLY 3 P=0.010** (e) (e) P=0.112 POLY 1.5 P=0.010** (e) (e) P=0.114 POLY 6 P=0.009** (e) (e) P=0.113 RAO-SCOTT P=0.049* (e) (e) P=0.237 LITTER C-A/FISHERS P=0.011* (e) (e) P=0.117 Adrenal Cortex Adenoma TUMOR RATES STATISTICAL TESTS Page 4 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 8/50 (16%) 3/50 (6%) 1/50 (2%) 0/50 (0%) LITTERS (b) 8/25 (32%) 3/25 (12%) 1/25 (4%) 0/25 (0%) POLY-3 RATE (c) 8/43.55 3/47.35 1/42.02 0/41.66 POLY-3 PERCENT (g) 18.4% 6.3% 2.4% 0% TERMINAL (d) 6/36 (17%) 3/42 (7%) 1/35 (3%) 0/37 (0%) FIRST INCIDENCE 675 743 (T) 743 (T) --- POLY 3 P<0.001N** P=0.074N P=0.018N* P=0.004N** POLY 1.5 P<0.001N** P=0.080N P=0.017N* P=0.004N** POLY 6 P<0.001N** P=0.072N P=0.019N* P=0.004N** RAO-SCOTT P=0.004N** P=0.106N P=0.034N* P=0.012N* LITTER C-A/FISHERS P<0.001N** P=0.085N P=0.012N* P=0.002N** Adrenal Medulla Pheochromocytoma Benign TUMOR RATES STATISTICAL TESTS Page 5 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS TUMOR RATES OVERALL (a) 8/50 (16%) 4/50 (8%) 1/50 (2%) 0/50 (0%) LITTERS (b) 8/25 (32%) 4/25 (16%) 1/25 (4%) 0/25 (0%) POLY-3 RATE (c) 8/43.55 4/47.35 1/42.02 0/41.66 POLY-3 PERCENT (g) 18.4% 8.5% 2.4% 0% TERMINAL (d) 6/36 (17%) 4/42 (10%) 1/35 (3%) 0/37 (0%) FIRST INCIDENCE 675 743 (T) 743 (T) --- POLY 3 P<0.001N** P=0.139N P=0.018N* P=0.004N** POLY 1.5 P<0.001N** P=0.147N P=0.017N* P=0.004N** POLY 6 P<0.001N** P=0.135N P=0.019N* P=0.004N** RAO-SCOTT P=0.003N** P=0.171N P=0.033N* P=0.012N* LITTER C-A/FISHERS P<0.001N** P=0.160N P=0.012N* P=0.002N** STATISTICAL TESTS Page 6 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) LITTERS (b) 2/25 (8%) 0/25 (0%) 0/25 (0%) 0/25 (0%) POLY-3 RATE (c) 2/43.13 0/47.35 0/42.02 0/41.66 POLY-3 PERCENT (g) 4.6% 0% 0% 0% TERMINAL (d) 2/36 (6%) 0/42 (0%) 0/35 (0%) 0/37 (0%) FIRST INCIDENCE 743 (T) --- --- --- POLY 3 P=0.121N P=0.217N P=0.243N P=0.245N POLY 1.5 P=0.119N P=0.222N P=0.241N P=0.243N POLY 6 P=0.123N P=0.213N P=0.244N P=0.244N RAO-SCOTT P=0.228N P=0.380N P=0.388N P=0.388N LITTER C-A/FISHERS P=0.114N P=0.245N P=0.245N P=0.245N Brain Granular Cell Tumor Benign TUMOR RATES STATISTICAL TESTS Page 7 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 5/50 (10%) 8/50 (16%) 8/50 (16%) 4/50 (8%) LITTERS (b) 5/25 (20%) 8/25 (32%) 7/25 (28%) 4/25 (16%) POLY-3 RATE (c) 5/43.30 8/47.35 8/42.02 4/41.66 POLY-3 PERCENT (g) 11.6% 16.9% 19% 9.6% TERMINAL (d) 4/36 (11%) 8/42 (19%) 8/35 (23%) 4/37 (11%) FIRST INCIDENCE 697 743 (T) 743 (T) 743 (T) POLY 3 P=0.401N P=0.336 P=0.255 P=0.524N POLY 1.5 P=0.386N P=0.321 P=0.263 P=0.518N POLY 6 P=0.404N P=0.345 P=0.247 P=0.524N RAO-SCOTT P=0.400N P=0.344 P=0.260 P=0.516N LITTER C-A/FISHERS P=0.317N P=0.260 P=0.371 P=0.500N Islets, Pancreatic Adenoma TUMOR RATES STATISTICAL TESTS Page 8 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 5/50 (10%) 9/50 (18%) 8/50 (16%) 4/50 (8%) LITTERS (b) 5/25 (20%) 9/25 (36%) 7/25 (28%) 4/25 (16%) POLY-3 RATE (c) 5/43.30 9/47.63 8/42.02 4/41.66 POLY-3 PERCENT (g) 11.6% 18.9% 19% 9.6% TERMINAL (d) 4/36 (11%) 8/42 (19%) 8/35 (23%) 4/37 (11%) FIRST INCIDENCE 697 666 743 (T) 743 (T) POLY 3 P=0.363N P=0.250 P=0.255 P=0.524N POLY 1.5 P=0.348N P=0.234 P=0.263 P=0.518N POLY 6 P=0.367N P=0.261 P=0.247 P=0.524N RAO-SCOTT P=0.364N P=0.258 P=0.258 P=0.515N LITTER C-A/FISHERS P=0.279N P=0.173 P=0.371 P=0.500N Islets, Pancreatic Carcinoma or Adenoma TUMOR RATES STATISTICAL TESTS Page 9 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 0/50 (0%) 0/50 (0%) 7/50 (14%) 11/50 (22%) LITTERS (b) 0/25 (0%) 0/25 (0%) 6/25 (24%) 8/25 (32%) POLY-3 RATE (c) 0/43.13 0/47.35 7/42.02 11/41.66 POLY-3 PERCENT (g) 0% 0% 16.7% 26.4% TERMINAL (d) 0/36 (0%) 0/42 (0%) 7/35 (20%) 11/37 (30%) FIRST INCIDENCE --- --- 743 (T) 743 (T) POLY 3 P<0.001** (e) P=0.007** P<0.001** POLY 1.5 P<0.001** (e) P=0.007** P<0.001** POLY 6 P<0.001** (e) P=0.006** P<0.001** RAO-SCOTT P<0.001** (e) P=0.050* P=0.010** LITTER C-A/FISHERS P<0.001** (e) P=0.011* P=0.002** Liver Hepatocellular Adenoma TUMOR RATES STATISTICAL TESTS Page 10 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 2/50 (4%) 2/50 (4%) 2/50 (4%) 1/50 (2%) LITTERS (b) 2/25 (8%) 2/25 (8%) 2/25 (8%) 1/25 (4%) POLY-3 RATE (c) 2/44.06 2/47.35 2/42.65 1/41.66 POLY-3 PERCENT (g) 4.5% 4.2% 4.7% 2.4% TERMINAL (d) 1/36 (3%) 2/42 (5%) 1/35 (3%) 1/37 (3%) FIRST INCIDENCE 302 743 (T) 533 743 (T) POLY 3 P=0.405N P=0.668N P=0.682 P=0.520N POLY 1.5 P=0.397N P=0.675N P=0.685 P=0.515N POLY 6 P=0.406N P=0.662N P=0.682 P=0.519N RAO-SCOTT P=0.397N P=0.661N P=0.666 P=0.502N LITTER C-A/FISHERS P=0.370N P=0.695 P=0.695 P=0.500N Mammary Gland Fibroadenoma STATISTICAL TESTS Page 11 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 3/50 (6%) 28/50 (56%) 26/50 (52%) 32/50 (64%) LITTERS (b) 3/25 (12%) 21/25 (84%) 20/25 (80%) 22/25 (88%) POLY-3 RATE (c) 3/43.13 28/47.90 26/42.21 32/41.81 POLY-3 PERCENT (g) 7% 58.5% 61.6% 76.5% TERMINAL (d) 3/36 (8%) 26/42 (62%) 24/35 (69%) 30/37 (81%) FIRST INCIDENCE 743 (T) 655 700 720 POLY 3 P<0.001** P<0.001** P<0.001** P<0.001** POLY 1.5 P<0.001** P<0.001** P<0.001** P<0.001** POLY 6 P<0.001** P<0.001** P<0.001** P<0.001** RAO-SCOTT P<0.001** P<0.001** P<0.001** P<0.001** LITTER C-A/FISHERS P<0.001** P<0.001** P<0.001** P<0.001** Pancreas Adenoma TUMOR RATES STATISTICAL TESTS Page 12 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 0/50 (0%) 3/50 (6%) 1/50 (2%) 3/50 (6%) LITTERS (b) 0/25 (0%) 3/25 (12%) 1/25 (4%) 3/25 (12%) POLY-3 RATE (c) 0/43.13 3/47.35 1/42.02 3/41.72 POLY-3 PERCENT (g) 0% 6.3% 2.4% 7.2% TERMINAL (d) 0/36 (0%) 3/42 (7%) 1/35 (3%) 2/37 (5%) FIRST INCIDENCE --- 743 (T) 743 (T) 726 POLY 3 P=0.152 P=0.137 P=0.495 P=0.113 POLY 1.5 P=0.155 P=0.132 P=0.497 P=0.114 POLY 6 P=0.153 P=0.140 P=0.493 P=0.113 RAO-SCOTT P=0.179 P=0.188 P=0.527 P=0.154 LITTER C-A/FISHERS P=0.160 P=0.117 P=0.500 P=0.117 Pancreas Carcinoma TUMOR RATES STATISTICAL TESTS Page 13 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 3/50 (6%) 29/50 (58%) 26/50 (52%) 32/50 (64%) LITTERS (b) 3/25 (12%) 21/25 (84%) 20/25 (80%) 22/25 (88%) POLY-3 RATE (c) 3/43.13 29/47.90 26/42.21 32/41.81 POLY-3 PERCENT (g) 7% 60.5% 61.6% 76.5% TERMINAL (d) 3/36 (8%) 27/42 (64%) 24/35 (69%) 30/37 (81%) FIRST INCIDENCE 743 (T) 655 700 720 POLY 3 P<0.001** P<0.001** P<0.001** P<0.001** POLY 1.5 P<0.001** P<0.001** P<0.001** P<0.001** POLY 6 P<0.001** P<0.001** P<0.001** P<0.001** RAO-SCOTT P<0.001** P<0.001** P<0.001** P<0.001** LITTER C-A/FISHERS P<0.001** P<0.001** P<0.001** P<0.001** Pancreas Carcinoma or Adenoma TUMOR RATES STATISTICAL TESTS Page 14 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm Pituitary Gland: Pars Distalis or Unspecified Site Adenoma TUMOR RATES OVERALL (a) 5/50 (10%) 6/50 (12%) 2/50 (4%) 2/50 (4%) LITTERS (b) 5/25 (20%) 5/25 (20%) 2/25 (8%) 2/25 (8%) POLY-3 RATE (c) 5/43.44 6/47.54 2/42.41 2/42.11 POLY-3 PERCENT (g) 11.5% 12.6% 4.7% 4.8% TERMINAL (d) 4/36 (11%) 5/42 (12%) 0/35 (0%) 1/37 (3%) FIRST INCIDENCE 655 694 683 609 POLY 3 P=0.107N P=0.563 P=0.225N P=0.228N POLY 1.5 P=0.103N P=0.547 P=0.222N P=0.226N POLY 6 P=0.106N P=0.573 P=0.227N P=0.226N RAO-SCOTT P=0.138N P=0.573 P=0.260N P=0.263N LITTER C-A/FISHERS P=0.103N P=0.637 P=0.209N P=0.209N STATISTICAL TESTS Page 15 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 3/50 (6%) 1/50 (2%) 0/50 (0%) 2/50 (4%) LITTERS (b) 3/25 (12%) 1/25 (4%) 0/25 (0%) 2/25 (8%) POLY-3 RATE (c) 3/43.13 1/47.35 0/42.02 2/41.66 POLY-3 PERCENT (g) 7% 2.1% 0% 4.8% TERMINAL (d) 3/36 (8%) 1/42 (2%) 0/35 (0%) 2/37 (5%) FIRST INCIDENCE 743 (T) 743 (T) --- 743 (T) POLY 3 P=0.467N P=0.273N P=0.123N P=0.516N POLY 1.5 P=0.460N P=0.281N P=0.122N P=0.512N POLY 6 P=0.470N P=0.267N P=0.124N P=0.514N RAO-SCOTT P=0.484N P=0.331N P=0.176N P=0.534N LITTER C-A/FISHERS P=0.443N P=0.305N P=0.117N P=0.500N Prostate Adenoma TUMOR RATES STATISTICAL TESTS Page 16 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma TUMOR RATES # # # # OVERALL (a) 6/50 (12%) 3/50 (6%) 1/50 (2%) 1/50 (2%) LITTERS (b) 6/25 (24%) 3/25 (12%) 1/25 (4%) 1/25 (4%) POLY-3 RATE (c) 6/43.13 3/47.35 1/42.24 1/41.66 POLY-3 PERCENT (g) 13.9% 6.3% 2.4% 2.4% TERMINAL (d) 6/36 (17%) 3/42 (7%) 0/35 (0%) 1/37 (3%) FIRST INCIDENCE 743 (T) 743 (T) 683 743 (T) POLY 3 P=0.030N* P=0.198N P=0.059N P=0.061N POLY 1.5 P=0.029N* P=0.209N P=0.058N P=0.060N POLY 6 P=0.031N* P=0.190N P=0.059N P=0.060N RAO-SCOTT P=0.041N* P=0.222N P=0.077N P=0.079N LITTER C-A/FISHERS P=0.023N* P=0.232N P=0.049N* P=0.049N* STATISTICAL TESTS Page 17 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 1/50 (2%) 5/50 (10%) 1/50 (2%) 1/50 (2%) LITTERS (b) 1/25 (4%) 5/25 (20%) 1/25 (4%) 1/25 (4%) POLY-3 RATE (c) 1/43.13 5/47.35 1/42.02 1/41.66 POLY-3 PERCENT (g) 2.3% 10.6% 2.4% 2.4% TERMINAL (d) 1/36 (3%) 5/42 (12%) 1/35 (3%) 1/37 (3%) FIRST INCIDENCE 743 (T) 743 (T) 743 (T) 743 (T) POLY 3 P=0.324N P=0.125 P=0.755 P=0.753 POLY 1.5 P=0.321N P=0.119 P=0.757 P=0.755 POLY 6 P=0.323N P=0.129 P=0.754 P=0.754 RAO-SCOTT P=0.357N P=0.163 P=0.747 P=0.744 LITTER C-A/FISHERS P=0.309N P=0.095 P=0.755 P=0.755 Skin Fibroma STATISTICAL TESTS Page 18 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm Skin Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Malignant Fibrous Histiocytoma TUMOR RATES # # # # OVERALL (a) 2/50 (4%) 5/50 (10%) 1/50 (2%) 2/50 (4%) LITTERS (b) 2/25 (8%) 5/25 (20%) 1/25 (4%) 2/25 (8%) POLY-3 RATE (c) 2/43.13 5/47.35 1/42.02 2/41.75 POLY-3 PERCENT (g) 4.6% 10.6% 2.4% 4.8% TERMINAL (d) 2/36 (6%) 5/42 (12%) 1/35 (3%) 1/37 (3%) FIRST INCIDENCE 743 (T) 743 (T) 743 (T) 720 POLY 3 P=0.389N P=0.256 P=0.509N P=0.682 POLY 1.5 P=0.384N P=0.246 P=0.506N P=0.685 POLY 6 P=0.388N P=0.263 P=0.511N P=0.685 RAO-SCOTT P=0.405N P=0.274 P=0.505N P=0.668 LITTER C-A/FISHERS P=0.368N P=0.209 P=0.500N P=0.695 STATISTICAL TESTS Page 19 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 5/50 (10%) 2/50 (4%) 1/50 (2%) 1/50 (2%) LITTERS (b) 5/25 (20%) 2/25 (8%) 1/25 (4%) 1/25 (4%) POLY-3 RATE (c) 5/43.13 2/47.35 1/42.24 1/41.66 POLY-3 PERCENT (g) 11.6% 4.2% 2.4% 2.4% TERMINAL (d) 5/36 (14%) 2/42 (5%) 0/35 (0%) 1/37 (3%) FIRST INCIDENCE 743 (T) 743 (T) 683 743 (T) POLY 3 P=0.068N P=0.180N P=0.105N P=0.109N POLY 1.5 P=0.066N P=0.189N P=0.104N P=0.107N POLY 6 P=0.069N P=0.174N P=0.106N P=0.108N RAO-SCOTT P=0.087N P=0.212N P=0.132N P=0.135N LITTER C-A/FISHERS P=0.055N P=0.209N P=0.095N P=0.095N Skin Keratoacanthoma STATISTICAL TESTS Page 20 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) LITTERS (b) 0/25 (0%) 2/25 (8%) 0/25 (0%) 0/25 (0%) POLY-3 RATE (c) 0/43.13 2/47.35 0/42.02 0/41.66 POLY-3 PERCENT (g) 0% 4.2% 0% 0% TERMINAL (d) 0/36 (0%) 2/42 (5%) 0/35 (0%) 0/37 (0%) FIRST INCIDENCE --- 743 (T) --- --- POLY 3 P=0.401N P=0.259 (e) (e) POLY 1.5 P=0.402N P=0.253 (e) (e) POLY 6 P=0.399N P=0.263 (e) (e) RAO-SCOTT P=0.490N P=0.404 (e) (e) LITTER C-A/FISHERS P=0.405N P=0.245 (e) (e) Skin Lipoma STATISTICAL TESTS Page 21 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm Skin Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma TUMOR RATES # # # # OVERALL (a) 5/50 (10%) 3/50 (6%) 1/50 (2%) 1/50 (2%) LITTERS (b) 5/25 (20%) 3/25 (12%) 1/25 (4%) 1/25 (4%) POLY-3 RATE (c) 5/43.13 3/47.35 1/42.24 1/41.66 POLY-3 PERCENT (g) 11.6% 6.3% 2.4% 2.4% TERMINAL (d) 5/36 (14%) 3/42 (7%) 0/35 (0%) 1/37 (3%) FIRST INCIDENCE 743 (T) 743 (T) 683 743 (T) POLY 3 P=0.057N P=0.307N P=0.105N P=0.109N POLY 1.5 P=0.055N P=0.319N P=0.104N P=0.107N POLY 6 P=0.058N P=0.298N P=0.106N P=0.108N RAO-SCOTT P=0.072N P=0.328N P=0.127N P=0.130N LITTER C-A/FISHERS P=0.045N* P=0.351N P=0.095N P=0.095N STATISTICAL TESTS Page 22 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm Skin Squamous Cell Papilloma, Papilloma, or Keratoacanthoma TUMOR RATES # # # # OVERALL (a) 5/50 (10%) 3/50 (6%) 1/50 (2%) 1/50 (2%) LITTERS (b) 5/25 (20%) 3/25 (12%) 1/25 (4%) 1/25 (4%) POLY-3 RATE (c) 5/43.13 3/47.35 1/42.24 1/41.66 POLY-3 PERCENT (g) 11.6% 6.3% 2.4% 2.4% TERMINAL (d) 5/36 (14%) 3/42 (7%) 0/35 (0%) 1/37 (3%) FIRST INCIDENCE 743 (T) 743 (T) 683 743 (T) POLY 3 P=0.057N P=0.307N P=0.105N P=0.109N POLY 1.5 P=0.055N P=0.319N P=0.104N P=0.107N POLY 6 P=0.058N P=0.298N P=0.106N P=0.108N RAO-SCOTT P=0.072N P=0.328N P=0.127N P=0.130N LITTER C-A/FISHERS P=0.045N* P=0.351N P=0.095N P=0.095N STATISTICAL TESTS Page 23 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 0/50 (0%) 0/50 (0%) 3/50 (6%) 0/50 (0%) LITTERS (b) 0/25 (0%) 0/25 (0%) 3/25 (12%) 0/25 (0%) POLY-3 RATE (c) 0/43.13 0/47.35 3/42.09 0/41.66 POLY-3 PERCENT (g) 0% 0% 7.1% 0% TERMINAL (d) 0/36 (0%) 0/42 (0%) 2/35 (6%) 0/37 (0%) FIRST INCIDENCE --- --- 725 --- POLY 3 P=0.501 (e) P=0.114 (e) POLY 1.5 P=0.510 (e) P=0.116 (e) POLY 6 P=0.501 (e) P=0.113 (e) RAO-SCOTT P=0.569 (e) P=0.243 (e) LITTER C-A/FISHERS P=0.539 (e) P=0.117 (e) Testes Adenoma TUMOR RATES STATISTICAL TESTS Page 24 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 11/49 (22%) 11/50 (22%) 4/50 (8%) 12/49 (24%) LITTERS (b) 8/25 (32%) 8/25 (32%) 3/25 (12%) 11/25 (44%) POLY-3 RATE (c) 11/42.22 11/47.77 4/42.02 12/41.94 POLY-3 PERCENT (g) 26.1% 23% 9.5% 28.6% TERMINAL (d) 11/36 (31%) 9/42 (21%) 4/35 (11%) 10/37 (27%) FIRST INCIDENCE 743 (T) 679 743 (T) 609 POLY 3 P=0.474 P=0.465N P=0.042N* P=0.493 POLY 1.5 P=0.484 P=0.495N P=0.041N* P=0.489 POLY 6 P=0.476 P=0.441N P=0.043N* P=0.509 RAO-SCOTT P=0.480 P=0.483N P=0.070N P=0.503 LITTER C-A/FISHERS P=0.253 P=0.619 P=0.085N P=0.280 Thyroid Gland: C-Cell Adenoma TUMOR RATES STATISTICAL TESTS Page 25 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 0/49 (0%) 3/50 (6%) 2/50 (4%) 1/49 (2%) LITTERS (b) 0/25 (0%) 3/25 (12%) 2/25 (8%) 1/25 (4%) POLY-3 RATE (c) 0/42.22 3/47.47 2/42.65 1/41.43 POLY-3 PERCENT (g) 0% 6.3% 4.7% 2.4% TERMINAL (d) 0/36 (0%) 2/42 (5%) 1/35 (3%) 1/37 (3%) FIRST INCIDENCE --- 711 533 743 (T) POLY 3 P=0.541 P=0.141 P=0.239 P=0.496 POLY 1.5 P=0.543 P=0.136 P=0.240 P=0.497 POLY 6 P=0.544 P=0.145 P=0.239 P=0.498 RAO-SCOTT P=0.538 P=0.189 P=0.282 P=0.524 LITTER C-A/FISHERS P=0.557 P=0.117 P=0.245 P=0.500 Thyroid Gland: C-Cell Carcinoma TUMOR RATES STATISTICAL TESTS Page 26 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm OVERALL (a) 11/49 (22%) 14/50 (28%) 6/50 (12%) 13/49 (27%) LITTERS (b) 8/25 (32%) 10/25 (40%) 5/25 (20%) 12/25 (48%) POLY-3 RATE (c) 11/42.22 14/47.90 6/42.65 13/41.94 POLY-3 PERCENT (g) 26.1% 29.2% 14.1% 31% TERMINAL (d) 11/36 (31%) 11/42 (26%) 5/35 (14%) 11/37 (30%) FIRST INCIDENCE 743 (T) 679 533 609 POLY 3 P=0.451 P=0.460 P=0.133N P=0.397 POLY 1.5 P=0.459 P=0.427 P=0.132N P=0.394 POLY 6 P=0.455 P=0.489 P=0.132N P=0.413 RAO-SCOTT P=0.452 P=0.476 P=0.167N P=0.415 LITTER C-A/FISHERS P=0.208 P=0.384 P=0.260N P=0.193 Thyroid Gland: C-Cell Carcinoma or Adenoma TUMOR RATES STATISTICAL TESTS Page 27 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated TUMOR RATES # # # # OVERALL (a) 3/50 (6%) 0/50 (0%) 0/50 (0%) 1/50 (2%) LITTERS (b) 3/25 (12%) 0/25 (0%) 0/25 (0%) 1/25 (4%) POLY-3 RATE (c) 3/43.33 0/47.35 0/42.02 1/42.39 POLY-3 PERCENT (g) 6.9% 0% 0% 2.4% TERMINAL (d) 2/36 (6%) 0/42 (0%) 0/35 (0%) 0/37 (0%) FIRST INCIDENCE 689 --- --- 478 POLY 3 P=0.264N P=0.104N P=0.124N P=0.313N POLY 1.5 P=0.259N P=0.107N P=0.122N P=0.312N POLY 6 P=0.267N P=0.102N P=0.126N P=0.311N RAO-SCOTT P=0.318N P=0.186N P=0.200N P=0.380N LITTER C-A/FISHERS P=0.245N P=0.117N P=0.117N P=0.305N STATISTICAL TESTS Page 28 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type TUMOR RATES # # # # OVERALL (a) 1/50 (2%) 2/50 (4%) 2/50 (4%) 0/50 (0%) LITTERS (b) 1/25 (4%) 2/25 (8%) 2/25 (8%) 0/25 (0%) POLY-3 RATE (c) 1/43.53 2/47.35 2/42.39 0/41.66 POLY-3 PERCENT (g) 2.3% 4.2% 4.7% 0% TERMINAL (d) 0/36 (0%) 2/42 (5%) 0/35 (0%) 0/37 (0%) FIRST INCIDENCE 624 743 (T) 659 --- POLY 3 P=0.319N P=0.529 P=0.491 P=0.509N POLY 1.5 P=0.313N P=0.522 P=0.494 P=0.506N POLY 6 P=0.321N P=0.533 P=0.489 P=0.509N RAO-SCOTT P=0.340N P=0.556 P=0.509 P=0.534N LITTER C-A/FISHERS P=0.294N P=0.500 P=0.500 P=0.500N STATISTICAL TESTS Page 29 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 32/50 (64%) 40/50 (80%) 31/50 (62%) 38/50 (76%) LITTERS (b) 22/25 (88%) 23/25 (92%) 22/25 (88%) 24/25 (96%) POLY-3 RATE (c) 32/44.97 40/48.09 31/43.14 38/42.26 POLY-3 PERCENT (g) 71.2% 83.2% 71.9% 89.9% TERMINAL (d) 27/36 (75%) 37/42 (88%) 26/35 (74%) 35/37 (95%) FIRST INCIDENCE 302 655 533 609 POLY 3 P=0.043* P=0.120 P=0.566 P=0.019* POLY 1.5 P=0.079 P=0.099 P=0.584N P=0.036* POLY 6 P=0.029* P=0.129 P=0.540 P=0.013* RAO-SCOTT P=0.050* P=0.132 P=0.556 P=0.028* LITTER C-A/FISHERS P=0.258 P=0.500 P=0.666 P=0.305 All Organs Benign Tumors STATISTICAL TESTS Page 30 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 9/50 (18%) 12/50 (24%) 8/50 (16%) 8/50 (16%) LITTERS (b) 8/25 (32%) 12/25 (48%) 6/25 (24%) 7/25 (28%) POLY-3 RATE (c) 9/45.96 12/48.03 8/43.72 8/44.09 POLY-3 PERCENT (g) 19.6% 25% 18.3% 18.1% TERMINAL (d) 4/36 (11%) 9/42 (21%) 4/35 (11%) 3/37 (8%) FIRST INCIDENCE 137 666 502 432 POLY 3 P=0.377N P=0.353 P=0.545N P=0.538N POLY 1.5 P=0.371N P=0.337 P=0.538N P=0.536N POLY 6 P=0.376N P=0.363 P=0.549N P=0.533N RAO-SCOTT P=0.382N P=0.359 P=0.541N P=0.534N LITTER C-A/FISHERS P=0.247N P=0.193 P=0.377N P=0.500N All Organs Malignant Tumors STATISTICAL TESTS Page 31 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid Route: DOSED FEED Species/Strain: RATS/HSD CAS Number: 335-67-1 First Dose M/F: 07/27/09 / NA Lab: BAT STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(HSD) TERMINAL SACRIFICE AT 107 WEEKS Males DOSE 0/0 ppm 0/20 ppm 0/40 ppm 0/80 ppm TUMOR RATES # # # # OVERALL (a) 37/50 (74%) 46/50 (92%) 35/50 (70%) 41/50 (82%) LITTERS (b) 24/25 (96%) 24/25 (96%) 22/25 (88%) 25/25 (100%) POLY-3 RATE (c) 37/47.56 46/48.77 35/44.76 41/44.54 POLY-3 PERCENT (g) 77.8% 94.3% 78.2% 92.1% TERMINAL (d) 28/36 (78%) 40/42 (95%) 27/35 (77%) 35/37 (95%) FIRST INCIDENCE 137 655 502 432 POLY 3 P=0.120 P=0.016* P=0.583 P=0.045* POLY 1.5 P=0.167 P=0.012* P=0.585N P=0.064 POLY 6 P=0.101 P=0.019* P=0.573 P=0.038* RAO-SCOTT P=0.154 P=0.034* P=0.584 P=0.076 LITTER C-A/FISHERS P=0.408 P=0.755 P=0.305N P=0.500 All Organs Malignant and Benign Tumors STATISTICAL TESTS Page 32 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 Experiment Number: 20614 - 02 Test Type: CHRONIC Route: DOSED FEED Species/Strain: RATS/HSD P08: STATISTICAL ANALYSIS OF PRIMARY TUMORS Perfluorooctanoic Acid CAS Number: 335-67-1 Date Report Requested: 06/06/2018 Time Report Requested: 17:57:11 First Dose M/F: 07/27/09 / NA Lab: BAT LEGEND (a) (b) (c) (d) (e) (f) (g) (I) (T) # * ** N Number of tumor-bearing animals/number of animals examined at site. Number of litters with tumor-bearing animals/number of litters examined at site Number of tumor-bearing animals/Poly-3 number Observed incidence at terminal kill. Value of statistic cannot be computed. Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. Poly-3 adjusted lifetime tumor incidence. Interim sacrifice Terminal sacrifice Tumor rates based on numbers of animals necropsied. To the right of any statistical result, indicates significance at (P<=0.05). To the right of any statistical result, indicates significance at (P<=0.01). Indicates a negative trend for all tests The Rao-Scott statistic performs the Poly-3 test with an adjustment for within-litter correlation. The Litter C-A/Fishers statistic compares directly the litter incidence rates. *** END OF REPORT *** Page 33