Message From: GOLDSTEIN, DANIEL A Sent: 9/29/2012 9:30:35 PM To: SACHS, ERIC 5 HAMMOND, BRUCE LEMKE, SHAWNA LIN HEYDENS, WILLIAM DAVID A VICINI, JOHN Subject: RE: URGENT: Quick Response Needed Serry? my ($009 e~rrieii is dawn?: just saw this. rem net en SECS guru? but here gees? ie Sid days yen are Seeking; for tdxieefdgy and rnest enirneis wiif stey beeitby in centrdi greeps: As yen ed fe iifefirne: two things bended a Edi: rndre enirneis die {net eii~ yen seerifiee at end df study befdre 109% and yer: begin be see backgrennd end less fredeent enteemes. There is tires need fer greater bi fe assure stetistieei brewer te discriminate better en these endpeints. ibis is any ntber statistical design prebiern? tire rnere neiee year have {variance} in the test and Centrei tire greater needed to stetistirzeiiy significant difference as {ice use statistics es en not efweys tbe rigid: test fer srneif Ni- fne sfenderd errdr of tbe rrieen {sensitivity te difference ernerig meens} is sigma sedered ever N. San From: SACHS, ERIC 1000] Sent: Saturday, September 29, 2012 5:54 AM To: HAMMOND, BRUCE 1000] GOLDSTEIN, DANIEL A 1000]; LEMKE, SHAWNA LIN 1000] HEYDENS, WILLIAM 1000] SALTMIRAS, DAVID A 1000] VICINI, JOHN 1000] Subject: URGENT: Quick Response Needed See question below. We need to help explain why 10 rats/sex/treatment is appropriate for 90? day studies but not for much longer studies. This is urgent. Eric Sachs Regulatory Policy Scientific Affairs Mobile:? _@monsanto.com Original From: Selim E-g?sabanc?un?ve?u] Sent: Saturday, September 29, 2012 05:34 AM Central Standard Time To: AgBioChatter@ Cc: Andrew Apel Subject: Re: Chatter: Founder of CRIIGEN defends Seralini Dear All, Corinne LePage's claims are now at GMWatch web site and widely used by the antis. I would appreciate some clarification on her claims especially the following ones that I used in my critique of Seralini's paper with the journalists. This was also one of the strongest points of the letter sent to Dr. Hayes. "The strain of rats selected is not appropriate" Interesting critique when you know it is the same strain as that used by Monsanto in its studies, which served as a basis for authorisations issued in Europe. If this strain is not valid then all authorisations must be withdrawn as they are based on ineffective tests. "The number of animals tested per group were insufficient" Except that no study has ever been conducted on as many animals (200) and the number of rats per group (10 [in Seralini's case, it was 10 of each sex]) is the same as the number used in all studies submitted to public bodies and validated by them comment: Monsanto used 20 rats per group in its 90-day study on NK603 but reportedly only analysed 10! See: de Vendomois, J. S., F. Roullier, et al. (2009). A comparison of the effects of three GM corn varieties on mammalian health. Biol Sci 706?726. 50 Lepage is correct in saying that no industry tests on a GMO submitted for approval have analysed more than 10 rats per group]. Consequently if that number does not allow conclusions to be drawn, then none of the studies that served for GMO authorisations could be taken into account either. Thanks Selim On 24.09.2012 23:27, Andrew Apel wrote: Corinne LePage, founder of CRIIGEN, strikes back at critics of Seralini's rat study. The original, just published by the Huf?ngton Post, is in French. This link should give you an automatic translation of the page: Selim Cetiner, Ph. D. Professor SabanCi University Faculty of Engineering and Natural Sciences Orhanli, Tuzla 34956 Istanbul, Turkey E?mail edu Phone Telefax Remix; to semis?" i Rania; to smug; Rsn?y sis was nest Start a New ?E?s-nit: Messages in this tank: Essays ?em?ms?s ?g?our {Imus}