Drug concentrations in wastewater treatment plant effluent, in ng/l. 1 nanogram (ng) = 0.001 microgram (µg) Drug BupropionCarbamazepine Celecoxib Diazepam Fexofenadine Fluconazole Metaxalone PNEC calculated by industry 10000 1100 27300 — — PNEC calculated by academic scientists 420 2000 250 Company Actavis Generics (owned by Teva) Mallinckrodt Inc Pharmaceuticals Group (SpecGx LLC) Mylan Pharmaceuticals Inc Pfizer* Pfizer Teva Pharmaceuticals (site sold to G&W Laboratories, Inc in 2015) Teva Women's Health Watson Laboratories (Closed in 2011). Silarx (now owned by Lannett) moved on site in 2013. WWTP Town of Davie Wastewater Treatment Plant Hobart Wastewater Treatment Plant Morgantown Utility Board Barceloneta Regional WWTP Town Pembroke Pines FL 1076 500 17400 6989 NY Morgantown WV Barceloneta PR Sellersville PA 730 Little Miami WWTP Cincinnati OH 436 Carmel Town Sewage District 2 NY Carmel 10600 Verapamil – State Hobart Pennridge Wastewater Treatment Authority WWTP Metoprolol Methadone Methocarbamol Phenytoin Temazepam — — 9883 1645 4770 5669 16400 17400 43842 Notes: * denotes samples taken before and after the phamaceutical manufacturing facility closed. Watson Laboratories bought Actavis in 2013 and changed its name to Actavis; in 2016, Actavis was purchased by Teva. 198 4119 554000 555000 2987 89463 Highest concentration from treatment plant with no drug manufactring waste 11904 17376 7790 248 76 7 3447 175 161 289 76 734 320 <80 41