OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Kevin T. Murphy COMMONS USER NAME (credential, agency login): TITLE: Professor and Vice Chair EU {Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) DEGREE Completion (if Date FIELD OF STUDY applicable) INSTITUTION AND LOCATION University of Notre Dame, Notre Dame, lndiana BS. 1989 Biological Sciences/Philosophy Purdue University, lndianapolis, Indiana MS. 1994 Neurophysiology University of?Chicago, Pritzker School of Medicine, MD. 1998 Medicine Chicago, iliinois A. Personal Statement I have for most of my career been keenly interested in the central nervous system (CNS) and have attempted to find new methods and technologies by which to protect and heal the CNS following injury. This has developed into a passion in the realm of which is a comparatively new neurotherapeutic modality by which to treat a wide range of disorders. lmportantly, is mechanistically orthogonal to all existing behavioral and pharmacological neurotherapies, and it is a more direct means by which to perturb deleterious neuroadaptations and pathways, compared to the pharmacobehavioral methods currently used to treat opioid addiction. I have developed a large and sophisticated treatment and research oriented TMS clinic as a satellite of UCSD, our program has blossomed, and we now treat numerous patients from across the United States and a wide range of CNS conditions, with marked success. We have obtained dramatic results in PTSD and autistic children and treated subjects with substance abuse disorders. Based on our encouraging pilot results with opioid addicted patients, and my experience in treating literally hundreds of patients with I am confident that Dr. Makaie?s proposed innovation of using frequent application via a practical, feasible delivery platform, to reduce opioid cravings and help prevent relapse, is scientifically sound. In my sophisticated, creative, and well formulated feasibility study. if this proposal is funded I will do everything I can to help this work succeed and I am very pleased to be a participant. B. Positions and Honors Positions US Navy US Naval Of?cer, Aboard Aircraft Carrier USS Ranger Engineering Division, Operation Desert Storm 1989-1992 internship Transitional Internship McNeal Hospital, Illinois July 01, 1998-June 30, 1999 Residency Radiation Oncology Department of Radiation and Cellular Oncology University of Chicago Hospitals, Chicago, Illinois July 01, 1999-June 30, 2003 Physician Private Practice, San Diego, CA X-Ray Medical Group 7/01i03-3i31/05 Assistant Professor Department of Radiation Medicine and Applied Sciences University of California San Diego, La Jolla CA 11/01/05-07/01/09 Associate Professor Department of Radiation Medicine and Applied Sciences University of California San Diego, La Jolla CA 07i01i09?06i30i2015 Vice Chairman Director of Pediatric Radiation Oncology Program 06/01i12-Present Professor Department of Radiation Medicine and Applied Sciences University of California San Diego, La Jolla CA 07/01i2015 to Present 2016 Best Doctor?s lnc., Voted Best Doctors in America 2015-16, San Diego Metro Magazine 2010 Bi-National Emergency Committee Award For Service'to Community 2000 University of Chicago, Department of Radiation and Cellular Oncology, Resident Research Award 1995 University of Chicago, Summer Research Forum Award C. Contributions to Science have a long-standing and consistent career trajectory that has been focused on the central nervous system (CNS) and CNS disorders. For my MS work I worked on hippocampal slices and long term potentiation (LTP), and after earning my MD and residency specialized in the radiotherapy of brain tumors. have contributed to several new approaches in this arena, such stereotaxic radiosurgery and intensity modulated radiotherapy in an attempt to maximize therapeutic gain but minimize CNS damage. I have been invited to speak at international venues to share my expertise and innovations in this area. Some key publications are listed below. Alksne J, Mundt AJ, Murphy KT. Single-Isocenter Frameless Intensity-Modulated Stereotactic Radiosurgery for Multiple Brain Metastasis. Int Radiat Oncoi Biol 2010. Nath SK, Lawson JD, Wang JZ, Simpson DR, Newman B, Alksne J, MunthJ, Murphy KT. Optically-Guided Frameless Stereotactic Radiosurgery for Brain Metastasis: Clinical Experience. Journai of Memo-Oncology 97:67?72, 2010. Lawson JD, Wang JZ, Nath SK, Rice R, Pawlicki T, MunthJ, Murphy KT. Intracranial Application of Based Radiosurgery to Treat Multiple or Large irregular Lesions and Verification of Infra?Red Frameless Localization System. Journai of Neuro?Oncoiogy 97:59-66, 2010. Nath SK, Carmona R, Rose BS, Simpson DR, Russell M, Lawson JD, Mundt AJ, Murphy KT. Observed Magnetic Resonance Imaging Changes in Pediatric Patients Treated with Stereotactic Radiosurgery for Intracranial Tumors, Childs Nervous System 2010 Mar; 27(3): 399-406. I then turned my attention to the novel methodology of surface guided radiotherapy as a method to attain more precise radiation dosing and have applied this for the treatment of unusual and morphologically challenging tumors such as acoustic neuroma. This is a very advanced technique that uses 3-D camera techniques to precisely map the target surface. I was among the first clinicians to utilize and adapt this approach to treating tumors, and report on my results. Jia X, Pawlicki T, Murphy KT, Mundt AJ. Proton Therapy Dose Calculations on GPU: Advances and Challenges. Translationai Cancer Research, 2012: (3). Pan H, Cervino Ll, Pawlicki T, Jiang SB, Alksne J, Detorie N, Russell M, Carter S, Murphy KT, MunthJ, Chen C, Lawson JD. Frameless, Real?Time Surface Imaging?Guided Radiosurgery: Clinical Outcomes for Brain Metastases. Neurosurgery, 2012: Manger R, Paravati A, Nguyen J, Olivares S, Kim G, Murphy KT. Initial clinical experience with surface image guided radiosurgery for trigeminal neuralgia. Translational Cancer Research, 2014 in press). Lau,S, Patel K, Kim T, Knipprath E, Kim GY, Cervino Ll, Lawson JD, Murphy KT, Sanghvi P, Hattangadi?Gluth JA, Carter BS and Chen CC. Clinical efficacy and safety of surface imaging guided radiosurgery in the treatment of benign skull base tumors. Submitted. have for many years observed firsthand in the clinic deeply concerning patterns of injury with intracranial radiation and profound cognitive deficits developing in adults and children. In recent years I and others aggressively explored new ways of minimizing this CNS damage with some success but in many cases CNS injury is unavoidable. This situation prompted me to investigate ways of treating such radiation therapy induced injury, and drawing on recent reports describing emerging repetitive transcranial magnetic stimulation technology began to intensively investigate and optimize this modality as a way of addressing radiation injury and after developing expertise, subsequently expanded my efforts and began to treat a wide range of disorders, including PTSD, depression, anxiety, and addiction. I am the first clinician to utilize sophisticated EEG power spectrum analysis along with other mathematically processed physiologic signals to determine what the natural dominant firing rate in a given patients cortex should be, and then treat with that frequency. Moreover, I am pioneering the development and implementation of carefully tailored pulses at low power to more precisely treat CNS disorders and remove the overwhelming and unnecessary neurological off target impact of high field strength treatment. Rahn, DA, Mundt, AJ, Murphy JD, Schiff D, Adams J, Murphy KT. Clinical Outcomes of Palliative Radiation Therapy for Children. Practical Radiation Oncology (PR. 0.), 2014. (In Press). Wang JZ, Rice R, Mundt, AJ, Sandhu AJ, Murphy KT. Feasibility and advantages of using flattening filter-free mode for radiosurgery of multiple brain lesions. Practical Radiation Oncology, April 2012: (2): 4: 165-171. McDuff SG, Taich ZJ, Lawson JD, Sanghvi P, Wong ET, Barker FG 2nd, Hochberg FH, Loef?er JS, Warnke PC, Murphy KT, MunthJ, Carter BS, McDonald CR, Chen C. Neurocognitive assessment following whole brain radiation therapy and radiosurgery for patients with cerebral metastases. Journal of Neuro?Oncology, 2013. Taghva A, Silvetz R, Ring A, Kim KYA, Murphy KT, Liu CY, Jin Y. Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder. Trauma Mon, November 2015: D. Additional Information: Research Support andlor Scholastic Performance Complete List of Published Work: 1. Alksne J, Mundt AJ, Murphy KT. Single-lsocenter Frameless Intensity?Modulated Stereotactic Radiosurgery for Multiple Brain Metastasis. Radiat Oncol Biol 2010. 2. Nath SK, Lawson JD, Wang JZ, Simpson DR, Newman B, Alksne J, Mundt AJ, Murphy KT. Optically-Guided Frameless Stereotactic Radiosurgery for Brain Metastasis: Clinical Experience. Journal of Neuro~Oncology 97:67?72, 2010. 3. Lawson JD, Wang JZ, Nath SK, Rice R, Pawlicki T, MunthJ, Murphy KT. lntracranial Application of IMRT Based Radiosurgery to Treat Multiple or Large Irregular Lesions and Verification of Infra-Red Frameless Localization System. Journal of Mauro-Oncology 97:59-66, 2010. 4. Nath SK, Carmona R, Rose BS, Simpson DR, Russell M, Lawson JD, MunthJ, Murphy KT. Observed Magnetic Resonance Imaging Changes in Pediatric Patients Treated with Stereotactic Radiosurgery for lntracranial Tumors, Childs Nervous System 2010 Mar; 27(3): 399-406. 5. Wang JZ, Rice R, Pawlicki T, MunthJ, Sandhu A, Lawson J, Murphy KT. Evaluation of Patient Setup Uncertainty of Optical Guided Frameless System for lntracranial Stereotactic Radiosurgery. JAppl Clin Med Phys. 2010 Apr 17:11 (2):3181. 6. Soanderbeg D. Alskne JF, Lawson JD, Murphy KT, Novel Use of the Contura for High Dose Rate Cranial Medical Dosimetry Dec 6, 2010:36 T. Wang JZ, Pawlicki T, Rice R, MunthJ, Lawson J, Sandhu A, Murphy KT. Intensity?Modulated Radiosurgery for Multiple Brain Metastasis Using RapidArc Technique and Comparison with the Static Approach. Medical Dosimetry, 2011 Spring;37 (1): 31 -6. 8. Pan H, Alksne J, MunthJ, Murphy KT, Cornell M, Kesari S, Lawson JD. Patterns of Imaging Failures in Glioblastoma Patients Treated with Chemoradiation:A Retrospective Study. Med Oncol, 2012: 3: 2040?5. 9. Cervino Ll, Detorie N, Taylor M, Lawson J, Henry T, Murphy KT, Mundt, AJ, Jiang SB, Pawlicki TA. Initial Clinical Experience with a Frameless and Maskless Stereotactic Radiosurgery Treatment. Practical Radiation Oncology, January 2012: 2 (1): 54- 62. 10. Jia X, Pawlicki T, Murphy KT, Mundt AJ. Proton Therapy Dose Calculations on GPU: Advances and Challenges. Translational Cancer Research, 2012: (3). 11. Pan H, Cervino Ll, Pawlicki T, Jiang SB, Alksne J, Detorie N, Russell M, Carter S, Murphy KT, MunthJ, Chen C, Lawson JD. Frameless, Real~Time Surface Imaging?Guided Radiosurgery: Clinical Outcomes for Brain Metastases. Neurosurgery, 2012: 12. Wang JZ, Rice R, Mundt, AJ, Sandhu AJ, Murphy KT. Feasibility and advantages of using flattening filter?free mode for radiosurgery of multiple brain lesions. Practical Radiation Oncology, April 2012: (2): 4: 165-171. 13. Waters JD, Rose B, Gonda DD, Scanderbeg DJ, Russell M, Alksne J, Murphy K, Carter BS, Lawson J, Chen CC. Immediate Post-Operative Prior to Irradiation and Temozolomide for Newly Diagnosed Glioblastoma. Journal of Mauro-Oncology, 2013: (3): 467- 477. 14. McDuff SG, Taich ZJ, Lawson JD, Sanghvi P, Wong ET, Barker FG 2nd, Hochberg FH, Loeffler JS, Warnke PC, Murphy KT, Mundt AJ, Carter BS, McDonald CR, Chen C. Neurocognitive assessment following whole brain radiation therapy and radiosurgery for patients with cerebral metastases. Journal of Neuro?Oncology, 2013. 15. Lau S, Murphy KT, Simpson D, Carmona R. Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases. Translational Cancer Research, 2014 (In press). 16. Manger R, Paravati A, Nguyen J, Olivares S, Kim G, Murphy KT. Initial clinical experience with surface image guided (SIG) radiosurgery for trigeminal neuralgia. Translational Cancer Research, 2014 (In ress). 17. Pham N, Reddy P, Murphy J, Sanghvi P, Hattangadi-Gluth J, Grace G, Cervino L, Pawlicki T, Murphy KT. Frameless, Real-time, Surface Imaging-Guided Radiosurgery: Update on Clinical Outcomes for Brain Metastases. Translational Cancer Research, August 2014. 18. Hesselink J, Barkovich M, Farid N, Kesari S, Murphy KT. Bevacizumab Radiation Combination Produces Restricted Diffusion on Brain MRI. CNS Oncology, 2014. (In press). 19. Rahn, DA, Mundt, AJ, Murphy JD, Schiff D, Adams J, Murphy KT. Clinical Outcomes of Palliative Radiation Therapy for Children. Practical Radiation Oncology (RR. 0.), 2014. (In Press). 20. Lau,S, Patel K, Kim T, Knipprath E, Kim GY, Cervino LI, Lawson JD, Murphy KT, Sanghvi P, Hattangadi-Gluth JA, Carter BS and Chen CC. Clinical efficacy and safety of surface imaging guided radiosurgery in the treatment of benign skull base tumors. Submitted. Research Support. Ongoing Research Support 2017 private gift for development of for central nervous system disorders. Completed Research Support 2013 $1 from the Allen Taylor Foundation, Research Award for the Development of Novel Therapies for Diseases of the Central Nervous System.