Personalized repetitive Transcranial MagneUc Stimulation Pr?l?qu DOWEQED BY meic?? PrTMS™ – The Passion Behind the One day, I treated a patient's brain like I treat other organs… Research  and the patient slept better and felt less anxious.  So I tried the treatment on another patient, and that patient regained focus, said he felt happier, and was more productive at work.   I then took a risk, and tried the treatment on a patient that flew across the country with a veterans-in-need organization, and that patient no longer felt suicidal. What really convinced me happened 4 years ago. I tried it on a child with autism who was not doing well in school, difficult to manage, and non-verbal.  His mom told me she feared he would need constant care for the rest of his life.  After a few months, that same child looked at me for the first time and - Kevin T. Murphy, said “I love you dad”.  M.D. Video of My Son Meet Jack Murphy Before and After PrTMS™ To play video, place curser at bottom of blue square Jack's Handwriting Samples over 5 months PROPRIETARY CONFIDENTIAL 2017 How Neurons Respond to Trauma Whether from tumor, surgery, chemotherapy, radiation, physical (concussion) or emotional trauma… Neurons slow their oscillation or frequency (self preservation) And become irregular and disorganized in their frequency “We treat the brain like an organ” Evolution of rTMS PrTMS Standard rTMS Modified rTMS Personalized rTMS Wireless Continuously EEG None EEG analysis None Cortical region DLPFC Wired w/ gel Every 10 sessions DLPFC Frequency 10 Hz Modified Personalized Motor Threshold 120% 80% Custom/Dynamic Trains/sessions 30 30 Custom/Dynamic 6 seconds 6 seconds Custom/Dynamic 54 seconds Depression and migraines 54 seconds Custom/Dynamic In trials Trials Written Train length Interval length FDA approval Multiple Cognionicsm Powered by Peaklogicm Wireless 19 Lead Dr QT) 95/? Second, below is a list of problems that people sometimes have in response to a very stressful experience. Keeping your worst event in mind, please read each problem carefully and then circle one of the numbers to the right to indicate how much you have been bothered by that problem in the past month. 't In the past month, how much were you bothered by: mm Moderately -m 1. Repeated, disturbing, and unwanted memories of the stressful experience? . Repeated, disturbing dreams of the stressful experience? 3. Suddenly feeling or acting as if the stressful experience were actually happening again (as if you were actually back there reliving it)? 4. Feeling very upset when something reminded you of the . 3 stressful experience? 1 5. Having strong physical reactions when something reminded you of the stressful experience (for example, heart pounding, trouble breathing, sweating)? 6. Avoiding memories, thoughts, or feelings related to the stressful experience? 7. Avoiding external reminders of the stressful experience (for example, people, places, conversations, activities, objects, or situations)? 8. Trouble remembering important parts of the stressful experience? 9. Having strong negative beliefs about yourself, other people, Mia 22 yo - Post-Concussion 3/13/17 3/20/17 3/24/17 3/28/17 4/7/17 4/12/17 4/13/17 4/26/Navy Vet PTSD 10/17/16 10/21/16 10/27/16 11/4/16 11/11/16 11/18/16 11/23/16 12/2/16 12/9/16 1/23/Examples of Neurobattery Scores 9/19/16 9/22/16 9/29/16 10/6/16 10/13/16 10/20/16 10/27/16 11/3/16 11/8/16 11/10/16 11/17/16 3/14/ . ?Planing 1.. TM 51min ?5 nu: lilrtl'llii ?r mun: ?5 ?nal . 9m? . ?m Hem Vim Arum-II t. I Jar??V ,rxd/ a ka?_ I ru?f? by; Wk x? fag?; \Eh?m a Real-time Monitoring During Qfg/?/ Treatment l. A. 6 week progress of Neuro-restoration qEEG’s of PrTMS for PTSD 01/14/14 01/30/14 02/19/14 03/07/14 Ideal Pediatric Cl 3 Organic Injury Cerebral Palsy Stroke Traumatic Brain Injury Concussive Syndrome Migraine NoiceptiveTinnitus Chronic Back Pain Chronic Neck Pain Fibromyalgia Neurodevelopme ntal Anxiety Psychologic Depression al Bipolar Disorder Obsessive-Compulsive Disorder Addiction Disorders MindSet Patient Population Autism Epilepsy Schizophrenia Tourette’s ADHD Chemobrain Opioid Dependence PTSD Alzheimer’s Parkinson’s Lyme’s Disease Dementia Orthographi c Neurodegenerativ e Evidence Based Research on PrTMS™ at MindSet, San Diego • Data collected from 2200+ patients since 2013 • 100 patient treatments scheduled per day • 8 PrTMS™ systems at capacity • 2 clinics for adults & pediatrics • 12 full time medical staf US Special Operations Command (USSOCOM) US. Special Operations Command 8. PeakLogic, inc. individual Work Plan to CRADA "Proof of Concept for Improving Human Performance in Special Operations Forces (SCI-7 Using Personalized Repetitive Transcranial Magnetic Stimulation ARTICLE A--PROJECT DESCRIPTION, PeakLogic, Inc. will collaborate with US. Special Operations Command (USSOCOM) in the conduct of a proof of concept an: render a report for improving human pedomance by using Personalized Repetitive TransCranial Magnetic Stimulation on Special Operations Forces (80F). ARTICLE B-QBJECTIVES 8.1 Cooperative Research and Development Agreement (CRADA) Objective This MP to the CRADA supports a mutually bene?cial evaluation that will inform a USSOQOM requirement to develop novel solutions and technologies in order to maximize the physiological performance of 80F Operators. USSOCOM Of?ce Science 8r Technology Directorate 49.. Lisa R. Sanders Name of Of?cial 60"? . ,Dc'jw-IJ Signature of Official Director Title of Official ?'70?i Tampa Point MacDill AFB, FL 33621 Address and E-maii of Official 26 May 201' 7' Date Signed Collaborator PeakLorgic. Inc. Kevin T. Murphy Name of Of?cial DxuSIun-Id by" ii We Signature of Official President Title of omcial 16918 Dove Canyon Road, Suite 20 San Diego, CA 9212? kevtmumh [@gmailcom Address and -mail of Of?cial 26 May 2017 Date Signed 10M Research Gift to Dr. Murphy for A UNIVERSITY OF CALIFORNIA SAN DIEGO BERKELEY . - - LOS - MERCED - SAN DIEGO - SAN FRANCISCO i I SANTA BARBARA SANTA CRUZ OF THE 9500 GIL-MAN DRIVE 0005 TEL: (853) 534-3135 LA JOLLA, CALIFORNIA 92093-0005 FAX: (85.8) 534-6523 EMAIL: URL: November 29, 2016 PRESIDENT JANET NAPOLITANO Of?ce of the President University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607 SUBJECT: REQUEST FOR GIFT ACCEPTANCE AUTHORIZATION Dear Janet: I am pleased to formally request authorization to accept a charitable bequest of $10 million ($10,000,000) from the Kreutzkamp Separate Property Trust, dated August 31, 2015, to the UC San Diego Foundation. This bequest is speci?cally for the support of the transcranial magnetic stimulation (TMS) research of Dr. Kevin Murphy, Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, UC San Diego Health. The bequest funds will be expended per the letter from Mr. Charles Kreutzkamp?s wife, Ernestina G. Kreutzkamp, dated June 2, 2016, which clari?es the donor?s intentions for the use of the gift in transcranial magnetic stimulation (TMS) research. These funds will be held as fully expendable funds for Dr. Murphy?s immediate research needs. Pending Clinical Trials Schedule Pending Clinical Trials Protocol Written Funde d IRB Submitted IRB Approved X X X X X X X X X X X X Chemobrain in • excel spreadsheet Adults Chemobrain in Children Neurocognitive Disorders in Children (Autism, CP) PTSD/TBI Veterans Concussion/CT E X Eb:23; 93mm :amino Clinic Expansion Plan: 2017 PrTMS powered by PeakLogic™ 1 PeakLogic Supported Clinic in Bozeman, MT: 2 Machines in use 1 MindSet owned and operated clinics: 8 machines (San Diego & Notre Dame University) 1 3rd party owned and PeakLogic supported locations - 1 machines (Notre Dame) 4 New Clinics: 5 Machines (Pending Contracts) 2 locations: MindSet owned and operated clinics: 2 machines (Carmel & Fort Wayne, IN) 2 locations: 3rd party owned and operated clinics (iKare & USSOCOM): 6 machines 8 Funded Research Locations for Clinical Trials: 33 machines • 1 location PrTMS Research Clinic/Suite 100 in San Diego: 11 machines • 6 locations for multi-site clinical trials outside of San Diego: 12 machines Market Opportunity: PeakLogic Target market - established physician practices • Physicians interested in PrTMS, preferably with an existing medical practice • Physician groups focused on mental health (depression, anxiety, PTSD, ASD) • Rehabilitation medicine centers (TBI, concussion, addiction, eating disorders) Other markets • Sports teams and training centers (i.e., NCAA, UFC, NFL) for concussion • Non-profit & public medical institutions with inpatient facility: LACMH, VA  Business Disclosure: www.prtms.com Non Profit 501c3 Focused on helping veterans.  Educational programs and funding resource to launch a national PrTMS mobile treatment solution for veterans who are living in remote areas, homeless, homebound, or hospitalized.  Treatment Centers Analytic Software Currently 2 centers located in San Diego and Bozeman. Patients receive PrTMS treatment and participate in clinical studies under the care of a physician. Treatment for depression, anxiety, sleep disorders, concussion, PTSD, and other neurocognitive disorders. An automated data & analytics platform used to process qEEG data and return a patient's intrinsic resonate frequency and ideal PrTMS treatment protocols based on patient's biological, environmental, & clinical assessment.