Frequently Asked Questions: Cornovavirus 1. What is Coronavirus? How is it different to the flu? - Coronaviruses are a type of RNA virus that are common throughout the world. Different types of coronavirus cause respiratory illness that may resemble influenza although the two types of virus are very different. Influenza is a negative strand RNA virus infecting both human and many animal species. 2. Can Coronavirus be transmitted through plasma products? - The 2019-nCoV is a large sized virus (approximately 120 nm in diameter). The relatively large size and lipid envelope makes it highly susceptible to steps with virus inactivation and removal capacity used during the manufacturing processes, such as pasteurization, solvent-detergent (S/D), low pH incubation, pasteurization, dry-heat treatment, and virus filtration. The effectiveness of these processes has been demonstrated on other coronavirus lipid-enveloped model viruses which are quite similar to 2019-nCoV, e.g. SARS-CoV, human coronavirus 229E and OC43, and porcine coronavirus TGEV. - Based on these data, we can be assured that existing manufacturing processes will provide significant safety margins for our plasma products against the 2019-nCoV. 3. Has CSL Plasma implemented any donor deferral measures in our collection centers? - While we are confident that there is no risk of viral contamination through our products, we have taken a prudent approach to protect the safety of our employees and the community by applying a temporary deferral of 28 days for any donor who has travelled to areas affected by 2019-nCoV or has been in close contact with an infected person. 4. Is CSL/Seqirus working on a Coronavirus vaccine? - Not directly. Coronavirus is quite different to influenza virus and is not a core area of focus for CSL/Seqirus. However given the public health issue that it has become, we are investigating possible adjacencies in expertise, technologies and facilities that we might be able to contribute to the global effort. - We have partnered with the University of Queensland in the development of their coronavirus vaccine program. We’ll provide scientific and biotech production expertise as well as a donation of Seqirus’ propriety adjuvant technology, MF59, to their pre-clinical development program. - The University of Queensland’s research program is just starting and it will be some months before the success of the program will be known. Our contribution in the pre-clinical development stage will be a humanitarian one and not commercial. WHAT’S HAPPENING IN CHINA 5. Are CSL operations in Wuhan still affected? - We have resumed production activities at our Wuhan facility on a limited basis with a small group of employees, focused on completing work related to the regulatory inspection that took place at the site in January. We are taking a number of precautions to ensure this facility is being operated in the safest way possible for our employees and products. - For now, our plasma collection centers and commercial operations sites in China remain closed. We are communicating regularly with our employees there, encouraging them and their family members to follow all of the safety recommendations coming from government and health officials. We also are reminding them about support that is available through our Employee Assistance Program (EAP) and other resources. We understand that this is a difficult and stressful time for all of our colleagues in China and we ask you to keep them in your thoughts. - We are continuing to secure and ship the infection control supplies, such as protective masks, that CSL leadership in China have requested. RESTRICTIONS ON BUSINESS AND PERSONAL TRAVEL 6. What are the current CSL travel restrictions? - With protecting the health and safety of our people as our top priority, all travel for CSL employees is limited to in-country for March 2020, effective as of 28 February. People who are currently traveling internationally should complete their business and return to their home countries immediately. These restrictions will remain in place throughout the month and will be re-evaluated at the end of March. An update will be provided at that time. Any business-critical exception to this travel restriction must be approved by a Global Leadership Group (GLG) member. - People are encouraged to optimize available communications technologies to continue conducting business and mitigate any business disruptions. This includes video conferencing, audio conferencing, the new TEAMS capability and other communications technologies. 7. What qualifies as business-critical travel? - “Business critical” is a significant hurdle. A good test would be to ask yourself, “Will the business stop within the month of March because I am not physically present?” 8. What should I do if I am uncomfortable traveling in-country right now because of the coronavirus? - If you are uncomfortable traveling in-country right now because of the evolving coronavirus situation, you should talk to your manager about rescheduling your trip or trying to find a way to use available communications technologies to continue conducting business. We do not want anyone to travel now who is uncomfortable doing so. 9. What if my commute to work involves crossing country borders? - Please speak with your manager if you cross a country border as part of your normal commute and you are required to be physically present at your work location and cannot work remotely. This exception needs to be approved by your GLG member. 10. Is traveling from Marburg to Bern considered international travel? - Yes, any travel that involves crossing country borders is considered international travel. 11. Are there any recommendations about personal travel to areas that have been impacted by the coronavirus? - We encourage employees to follow travel guidance from local government and health officials. Employees who have recently visited or plan to visit mainland China, Hong Kong, Macau, South Korea and northern Italy are asked to inform their manager. Upon your return, you may be asked to self-quarantine for a period of 14 days. 12. When will a decision be made on whether CSL will extend the travel restrictions beyond the end of March? - The situation involving the coronavirus is continuing to evolve on a daily basis. Our Global Leadership Group and Global Crisis Team are monitoring the outbreak closely. We are following guidance from local government and health officials as we make decisions. Ensuring the safety of our people and patients are our top priorities. We will share a decision on whether CSL will continue to limit travel beyond March 2020 as soon as possible. 13. I have plans to travel internationally in March. Will my reservations be cancelled automatically? - No, you need to cancel and/or reschedule any travel arrangements. 14. If I have just returned from a trip overseas, can I return to work? - Given the rapidly changing situation, it is important that you follow the advice of your local government and health officials. If you have just returned from a business or personal trip to mainland China, Hong Kong, Macau, South Korea or parts of northern Italy, please reach out to your manager. You may be asked to monitor your health and self-quarantine for a 14-day period. 15. I booked personal trips as part of upcoming business travel, which has now been cancelled due to CSL’s travel restrictions. Can I be reimbursed by the company? - No. Business travel can be cancelled for a variety of reasons and CSL does not reimburse employees for personal expenses that were incurred because of changes in business-related travel. RESTRICTIONS ON VISITORS TO OUR SITES 16. Are we screening visitors to our sites to see if they have recently been to areas impacted by the coronavirus? - Some of our sites currently are not allowing visitors. Others are asking visitors, contractors and contingent workers who are coming to our sites if they have been to areas such as mainland China, Hong Kong, Macau, South Korea and northern Italy that have been impacted by the coronavirus. We reserve the right to deny access to our sites for anyone who has potentially been exposed to the coronavirus. If your site is still allowing visitors, please make certain that they are aware that CSL has restrictions in place. 17. Should suppliers or visitors from overseas be allowed on site? - Restrictions currently vary from site to site, so please check with your location regarding whether visitors are currently being allowed onsite. WORKING FROM HOME 18. Are we being encouraged to work from home at this point? - Currently, decisions on employees working from home are being made at the location level, based on the severity of the coronavirus outbreak in your area. As a precautionary measure, you should be taking anything you need to work from home, such as laptops, etc., with you every day. INFECTION PREVENTION REMINDERS 19. What infection prevention steps should employees take to safeguard themselves from exposure to coronavirus?        Wash your hands often with soap and water for at least 20 seconds. Use alcohol-based hand sanitizer. Avoid touching your eyes, nose and mouth with unwashed hands. Avoid close contact to sick people. Stay at home, if you show suspicious symptoms (f.ex. fever, cough). Sneeze and cough in the crook of the arms and turn away from other persons. Dispose of your tissue in a trash/rubbish bin after single use. 20. Do I need to wear a face mask at work? - No, a mask does not adequately protect healthy people from an infection of coronavirus. However, if symptoms of illness such as breathing difficulties, cough or fever appear, and you have to leave the house for e.g. a visit to the doctor, then you should protect others from infection by wearing a mask. GETTING CSL UPDATES ON CORONAVIRUS 21. What should people managers do to help address the coronavirus situation? - Make sure that employees in your team, particularly those who lack regular access to email, are aware of our travel restrictions and other measures being taken to monitor the coronavirus situation and address it. - Talk to your employees about any upcoming business trips they have scheduled and have them make changes in their plans, if needed, to comply with the company’s current travel restrictions. 22. How can employees get the latest CSL updates on coronavirus? - Check our communication channels such as CSL Global News and the CSL NOW employee mobile app regulary for CSL updates on the coronavirus situation. - CSL has a mass notification system to notify employees when our sites are closed, have a delayed opening or in the event of an emergency. To help ensure you receive these messages, you need to have your most up-to-date information, including a mobile phone number, in Workday. Please go into Workday now and verify that your information is accurate and complete.